CID 5951923, also known as a cell-permeable phenylpropenoate compound, is a chemical entity that has been identified for its potential applications in the field of cancer research and treatment. It is particularly effective in inhibiting the proliferation of colon cancer cell lines that exhibit high levels of KLF5. CID 5951923 works by downregulating the expression of early growth response protein 1 (EGR1), which in turn modulates KLF5 expression at the transcriptional level. Additionally, CID 5951923 has been shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204, as well as up-regulating the phosphorylation of p38 MAPK-Thr180/Tyr182.
749872-43-3
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Basic information
- Product Name: CID 5951923
- Synonyms: [2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;AC1NZ6UQ;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;KLF5 Inhibitor, CID 5951923;CID 5951923;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
- CAS NO:749872-43-3
- Molecular Formula: C16H18N2O7S
- Molecular Weight: 382.38832
- EINECS: N/A
- Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 749872-43-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: room temp
- Solubility: DMSO: soluble10mg/mL (clear solution)
- CAS DataBase Reference: CID 5951923(CAS DataBase Reference)
- NIST Chemistry Reference: CID 5951923(749872-43-3)
- EPA Substance Registry System: CID 5951923(749872-43-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 749872-43-3(Hazardous Substances Data)
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749872-43-3 Usage
Uses
CID 5951923 is used as a KLF-5 expression inhibitor for reducing proliferation cell rates in colorectal cancer cells in humans. By inhibiting KLF-5 expression, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate can potentially slow down the growth of colorectal cancer cells and contribute to the development of novel cancer treatment strategies.Used in Pharmaceutical Industry:
CID 5951923 is used as a potential therapeutic agent for colorectal cancer treatment. Its ability to inhibit KLF-5 expression and modulate various signaling pathways makes it a promising candidate for further research and development in the pharmaceutical industry. CID 5951923 could potentially be utilized in the design of new drugs or drug delivery systems targeting colorectal cancer cells with high KLF-5 expression levels.
Used in Cancer Research:
CID 5951923 is used as a research tool for studying the role of KLF-5 in colorectal cancer cell proliferation and the underlying molecular mechanisms involved. Understanding the interactions between 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate and various cellular pathways can provide valuable insights into the development of targeted cancer therapies and the potential for combination treatments with conventional chemotherapeutic drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 749872-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,9,8,7 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.Calculate Digit Verification of CAS Registry Number 749872-43:
(8*7)+(7*4)+(6*9)+(5*8)+(4*7)+(3*2)+(2*4)+(1*3)=223
223 % 10 = 3
So 749872-43-3 is a valid CAS Registry Number.
749872-43-3 Well-known Company Product Price
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CID 5951923
