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Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo propinic acid dodecyl ester is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its reactivity and unique chemical structure to facilitate the creation of new medicinal compounds.
Used in Cosmetics Industry:
In the cosmetics industry, 2-Bromo propinic acid dodecyl ester is used as a surfactant or emulsifier, helping to stabilize formulations and improve the texture and consistency of products, thanks to its properties as a dodecyl ester.
Used in Detergent Industry:
2-Bromo propinic acid dodecyl ester is utilized as a surfactant in detergents, contributing to the cleaning and emulsifying properties of these products, which is essential for their effectiveness in various cleaning applications.
Used in Research Settings:
In research, 2-Bromo propinic acid dodecyl ester is employed for studying its unique chemical properties and exploring its potential applications in the development of new materials and compounds, further expanding its utility across various scientific disciplines.

Upstream product

• 112-53-8 1-dodecyl alcohol 
• 563-76-8 α-bromopropionyl bromide 

Relevant academic research and scientific papers

Evaluation of adjuvants that enhance the effectiveness of antisense oligodeoxynucleotides

Purpose. A factor limiting the effectiveness of antisense (AS) deoxyoligonucleotides (ODNs) is inefficient transport to their sites of action in the cytoplasm and in the nucleus. The extent of ODN transfer from endosomes to cytosol seems to be an important determinant of ODN effects. Consequently, the development of compounds (adjuvants) that enhance endosome to cytosol transfer may be vital in AS ODN therapeutics. Methods. In this report, we evaluated compounds for their potential to enhance the effects of phosphorothioate ODNs. The test system used a CHO cell line expressing the enzyme chloramphenicol acetyltransferase (CAT) under the control of an inducible promoter. Several potential endosomal disrupting adjuvants were screened, including: (a) fusogenic peptides; (b) a pH sensitive polymer; (c) polymeric dendrimers, (d) cationic liposomes and (e) a pH sensitive surfactant N-dodecyl 2-imidazole-propionate (DIP). ODN effects were evaluated at the protein level by quantitating levels of CAT. Results. The use of AS ODN in co-incubation with the GALA peptide, cationic liposomes or 5th generation dendrimers resulted in a 35-40% reduction in CAT expression. The mis-matched ODN had no effect on CAT expression. Only modest effects were observed with the other adjuvants. DIP did not increase ODN activity by itself; however, when the liposomal form was used a significant reduction (48%) in CAT activity was seen. Conclusions. We found the fusogenic peptide GALA, dendrimers, as well as the liposomal form of DIP, could significantly enhance the effects of ODNs.

ANTIMICROBIAL COMPOUNDS AND METHODS OF USE

The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are e