749886-77-9Relevant academic research and scientific papers
Highly selective synthesis of 2-substituted-5-hydroxy-6-oxo-1,6- dihydropyrimidine-4-carboxylic acid derivatives using a novel protected dihydroxyfumarate
Dreher, Spencer D.,Ikemoto, Norihiro,Gresham, Venita,Liu, Jinchu,Dormer, Peter G.,Balsells, Jaume,Mathre, David,Novak, Thomas J.,Armstrong III, Joseph D.
, p. 6023 - 6025 (2004)
A high yielding (50-96%) route to 2-substituted-5-hydroxy-6-oxo-1,6- dihydropyrimidine-4-carboxylic acid derivatives has been developed using a rationally designed dihydroxyfumarate derivative. The fully unprotected pyrimidinone heterocycle was prepared i
