749920-53-4

Upstream product

• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 106-54-7 p-Chlorothiophenol 
• 103-84-4 Acetanilid 

Downstream Products

• 1309389-06-7 methyl 2-((2-(4-chlorophenylthio)quinolin-3-yl)(hydroxy)methyl)acrylate 
• 1376342-30-1 2-amino-4-(2-(p-chlorophenylthio)quinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile 
• 1376342-50-5 2-amino-4-(2-(p-chlorophenylthio)quinolin-3-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile 
• 1376342-65-2 2-amino-4-(2-(p-chlorophenylthio)quinolin-3-yl)-5-oxo-9-methyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile 
• 1410808-60-4 2-amino-6-(4-chlorophenylthio)-4-(2-(phenylthio)quinolin-3-yl)pyridine-3,5-dicarbonitrile 
• 1410808-64-8 2-amino-4-(2-(4-chlorophenylthio)quinolin-3-yl)-6-(phenylthio)pyridine-3,5-dicarbonitrile 
• 1410808-65-9 2-amino-4-(2-(4-chlorophenylthio)quinolin-3-yl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile 
• 1410808-66-0 2-amino-6-(4-chlorophenylthio)-4-(2-(4-chlorophenylthio)quinolin-3-yl)pyridine-3,5-dicarbonitrile 
• 1620402-57-4 C₃₄H₂₆ClF₃N₄OS 
• 1620402-63-2 C₃₇H₃₃ClF₃N₃O₃S 

Relevant academic research and scientific papers

Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation

A new series of 2-thiophenoxyquinolines based trifluoromethyl substituted N-aryl quinolone derivatives 8a-f and 9a-f have been synthesized via a one-pot multicomponent reaction. In vitro antimicrobial activity of the synthesized compounds was investigated

Schiff's base derivatives bearing 2-thiophenoxyquinoline nucleus as new antibacterial agents

A series of new Schiff's base derivatives 4a-x bearing 2- thiophenoxyquinoline nucleus have been designed and synthesized by reaction of 2-thiophenoxyquinoline-3-carbaldehydes 2a-d with various benzohydrazides 3a-f in the presence of Ni(NO3)su

Synthesis and in vitro antimicrobial evaluation of novel 2-amino-6-(phenylthio)-4-(2-(phenylthio)quinolin-3-yl)pyridine-3, 5-dicarbonitriles

A new series of 2-thiophenoxyquinoline-based penta-substituted pyridine derivatives, 6(a-r), has been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction (MCR) approach. In vitro antimicrobial activity of the synthesi

Synthesis and antimicrobial evaluation of new pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives bearing a 2-thiophenoxyquinoline nucleus

A new series of pyrano[4,3-b]pyran 4a-i and pyrano[3,2-c]chromene 6a-r derivatives bearing a 2-thiophenoxyquinoline nucleus were synthesized by reaction of 2-(4-(un)-substituted thiophenoxy)quinoline-3-carbaldehydes 2a-i with 6-methyl-4-hydroxypyran-2-one

First construction of 12H-thiochromeno[2,3-b]quinolines and 5H-benzo[7,8]thiocino-[2,3-b]quinolines via intramolecular Friedel-Crafts reaction of Morita-Baylis-Hillman adducts

An acid-promoted intramolecular Friedel-Crafts reaction of the Morita-Baylis-Hillman adducts 3 derived from 2-arylthioquinolin-3-carbaldehydes 2 was investigated. Interestingly, promoted by sulfuric acid, the substrates with electron-donating groups on the aromatic ring gave six-membered fused-ring 12H-thiochromeno[2,3-b]quinolines 4 with good yields, while those with electron-withdrawing groups afforded eight-membered fused-ring 5H-benzo[7,8]thiocino[2,3-b]quinolines 5 in moderate yields. Using triflic acid instead of sulfuric acid, only products 4 could be obtained under the similar condition.