749929-01-9Relevant academic research and scientific papers
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
Li, Hui,Tatlock, John,Linton, Angelica,Gonzalez, Javier,Jewell, Tanya,Patel, Leena,Ludlum, Sarah,Drowns, Matthew,Rahavendran, Sadayappan V.,Skor, Heather,Hunter, Robert,Shi, Stephanie T.,Herlihy, Koleen J.,Parge, Hans,Hickey, Michael,Yu, Xiu,Chau, Fannie,Nonomiya, Jim,Lewis, Cristina
, p. 1255 - 1258 (2009)
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhibitio
