749929-13-3

Upstream product

• 749928-77-6 2-(4-bromo-2-fluoro-phenyl)-2-methyl-propionitrile 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 114897-91-5 (4-bromo-2-fluorophenyl)acetonitrile 
• 749928-76-5 2-{4-[3-cyclopentyl-4-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-3-hydroxybutyl]-2-fluorophenyl}-2-methyl-propionitrile 
• 749928-78-7 2-{4-[3-cyclopentyl-4-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-3-hydroxybut-1-ynyl]-2-fluoro-phenyl}-2-methyl-propionitrile 

Relevant academic research and scientific papers

Development of a synthetic process towards a hepatitis C polymerase inhibitor

The synthesis of 2-(4-{2-[(2R)-2-Cyclopentyl-5-(5,7-dimethyl-[1,2,4] triazolo[1,5-a]pyrimidin-2-ylmethyl)-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl] -ethyl}-2-fluoro-phenyl)-2-methyl-propionitrile (1) on multikilogram scale is described. Initial synthesis