Welcome to LookChem.com Sign In|Join Free
  • or

75-12-7

Post Buying Request

75-12-7 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Formamide, FMA, China factory, on hot sale, best quality with competitive price
Cas No: 75-12-7
No Data 1 Metric Ton 500 Metric Ton/Month Zibo Kunran Enterprises Co. LTD Contact Supplier
High purity Formamide 98% TOP1 supplier in China
Cas No: 75-12-7
No Data 100 Gram Metric Ton/Day Hangzhou Dayangchem Co., Ltd. Contact Supplier
Formamide Manufacturer
Cas No: 75-12-7
USD $ 2.0-2.0 / Metric Ton 1 Metric Ton 10000 Metric Ton/Year Antimex Chemical Limied Contact Supplier
Good quality Formamide,75-12-7
Cas No: 75-12-7
No Data 1 Kilogram 1000 Metric Ton/Day Hefei TNJ chemical industry co.,ltd Contact Supplier
Formamide CAS 75-12-7
Cas No: 75-12-7
USD $ 130.0-150.0 / Gram 10 Gram 200 Metric Ton/Month Hebei Huanhao Biotechnology Co.,Ltd Contact Supplier
Hot sale Formamide 99%min CAS NO.75-12-7
Cas No: 75-12-7
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High quality Methanamide
Cas No: 75-12-7
USD $ 1.0-1.0 / Kilogram 10 Kilogram 50 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier
Quality guaranteed Formamide 75-12-7 sulfa drugs on hot selling
Cas No: 75-12-7
USD $ 3000.0-4300.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High purity Formamide CAS 75-12-7 with factory price
Cas No: 75-12-7
USD $ 1.5-2.5 / Kilogram 220 Kilogram 600 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Formamide
Cas No: 75-12-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier

75-12-7 Usage

Storage properties

Warehouse: cold, ventilation, dry.

Health Hazard

INHALATION: A moderate irritant to mucous membranes. EYES: Moderately irritating to the eyes. SKIN: A mild to moderate irritant to the skin.

Production method

1. One-Step method: the first step is through the reaction of carbon monoxide and methanol for generating methyl formate in the presence of sodium methoxide. The second step: the methyl formate is further subject to aminolysis for generation of formamide with the reaction conditions being 80-100 ℃ and 0.2-0.6 MPa. This method has relative problems. 2. The method of formic acid; the formic acid first has esterification reaction with methanol to generate methyl formate which undergoes aminolysis to generate formamide with the separation of methanol and impurities through distillation to obtain the final product. Owing to its high cost, this method has been gradually eliminated. 3. One Step method: this is via the reaction of carbon monoxide and ammonia for the direct synthesis of formamide in high pressure (10-30 MPa) and a temperature of 80-100 ℃ with the sodium methylate as the catalyst. 4. The formic acid and urea method. 5. The new method has sodium and ammonium salts for reaction to generate formamide at a certain temperature and pressure. This method has already applied domestic invention patent.

Purification Methods

Formamide is easily hydrolysed by acids and bases. It also reacts with peroxides, acid halides, acid anhydrides, esters and (on heating) alcohols, while strong dehydrating agents convert it to a nitrile. It is very hygroscopic. Commercial material often contains acids and ammonium formate. Vorhoek [J Am Chem Soc 58 2577 1956] added some bromothymol blue to formamide and then neutralised it with NaOH before heating to 80-90o under reduced pressure to distil off ammonia and water. The amide is again neutralised and the process is repeated until the liquid remained neutral on heating. Sodium formate is added, and the formamide is concentrated under reduced pressure at 80-90o. The distillate is again neutralised and redistilled. It is then fractionally crystallised in the absence of CO2 and water by partial freezing. Formamide (specific conductance 2 x 10-7 ohm-1 cm-1) of low water content is dried by passage through a column of 3A molecular sieves, then deionized by treatment with a mixed-bed ion-exchange resin loaded with H+ and HCONH-ions (using sodium formamide in formamide)[Notley & Spiro J Chem Soc (B) 362 1966]. [Beilstein 2 IV 45.]

General Description

A colorless liquid with a faint odor of ammonia. Denser than water. Freezing point 36°F.

Definition

ChEBI: The simplest monocarboxylic acid amide, obtained by formal condensation of formic acid with ammonia. The parent of the class of formaldehydes.

Extinguishing Media

Carbon dioxide, dry chemical powder.

Chemical Properties

It is transparent oily liquid with slight ammonia smell. It has hygroscopic property. It is miscible with water and ethanol, slightly soluble in benzene, chloroform and ether.

Flammability and hazardous characteristics

Flammable with fire releasing toxic nitric oxide gas.

Irritation data

Eye-rabbit 100 mg severe.

Chemical Properties

It is colorless, odorless and oily liquid with slight ammonia-odor when containing impurities. It has hygroscopicity property. It has a relative molecular mass of 45.04. It has the relative density being 1.1334, the melting point being 2.55 ℃, the boiling point being 210.5 ℃, the refractive index being 1.4475, the flash point being 154 ℃ and the viscosity being 3.76mPa ? s (20 ℃). It is insoluble in ether and chlorinated solvents, slightly soluble in benzene and is miscible with water, methanol, ethanol, acetic acid, acetone, dioxane, ethylene glycol, phenol and low grade ester. This product can dissolve the casein but does not dissolve albumin. This product can dissolve casein, dextrose, corn protein, gelatin, glue, resin, starch, lignin, cellulose acetate, nylon, and some inorganic salts: the chloride compounds of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel and also some kinds of sulfates and nitrates. At room temperature, formamide has a low hydrolysis rate. Raising the temperature or the addition of acid, alkali can all accelerate the hydrolysis rate. In the presence of a catalyst, being heated to less than 35 ℃ can decompose and release hydrogen cyanide. Formamide contains two active functional groups, namely the carbonyl and amide groups. It is easy to have chemical reaction to produce a lot of nitrogen-containing heterocyclic compound. Formamide can also react with a mineral acid to generate formic acid and ammonium salt. In the presence of a catalyst, it can react with organic halide or alcohol to form formic esters. This product can also react with β-diketone, β-imino ketone, aliphatic acyloin, arene acyloin as well as heterocyclic acyloin. It can also form complex with cobalt, copper and nickel salts. Formamide, in case of strong dehydrating agent such as phosphorus pentoxide, it can generate hydrogen cyanide. It can react with phosphorus pentasulfide to generate sulfur formamide. Formamide has strong corrosion effect on copper, brass, lead and rubber, therefore the storage and transportation should be paid attention.
The main purposes: formamide can be used as the softener and solvent of animal glue and paper. It can also be used as the solvent of the spinning of the acrylonitrile copolymer, the polymerization of unsaturated amine polymerization and the production of pharmaceuticals as well as the solvent for extraction of grease and the dissolving items mentioned above. As intermediates, it can be applied the synthesis of imidazole, pyrimidine, 1, 3, 5-triazine, caffeine, theophylline and theobromine. Furthermore, it can also be used as the raw material of making dyes, spices, paints, adhesives, textile and paper treatment agent as well as the production of formic acid, dimethyl formamide and so on.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Uses

It can be used as the raw material for synthesizing imidazole, pyrimidine, 1, 3, 5-triazine, caffeine as well as the solvents for making spinning of acrylonitrile copolymer and plastic anti-static coating, etc.
Formamide has active reactive and special dissolving capability. It can be used as the raw material for organic synthesis, paper processing agents, softening agent of fiber industry and animal glue as well as being used as the analytical reagent for measuring the amino acid content of rice. In the field of organic synthesis, it has most application in medicine as well as a lot of applications in other fields such as pesticides, dyes, pigments, fragrances and additives. It is also a kind of excellent organic solvent and is mainly applied to the spinning of acrylonitrile copolymers and ion exchange resins and plastics antistatic coating or conductive coating. In addition, it can also be used for separating chlorosilane and purifying grease. Formamide can have various kinds of reactions, in addition to have its three hydrogen atoms participate in the reaction, can also be subject to dehydration, CO removal, the introduction of an amino group, an acyl group and cyclization reaction. Take cyclization as an example, diethyl malonate can have cyclization reaction with formamide to generate the intermediate of vitamin B4, the 4, 6-dihydroxypyrimidine. O-aminobenzoic acid can have cyclization reaction with formamide to generate the quinazolinone-4 which is the intermediate for the synthesis of antiarrhythmic drug phenantrolihne. 3--amino-4-ethoxycarbonyl-pyrazole can have cyclization reaction with formamide to generate the inhibitor of the xanthine oxidase, allopurinol. EDTA can have cyclization reaction with formamide to give anti-cancer drugs ethylenediamine. Methyl ethyl methoxymalonate can have cyclization reaction with formamide to generate the intermediate of sulfonamide drug, 5-methoxy-4, 6-dihydroxy pyrimidine disodium.
It can be used as analytical reagents, solvents and softening agents as well as being used in organic synthesis.
It can be applied to medicine and pesticide industry.

Chemical Properties

It is transparent oily liquid with slight ammonia smell. It has hygroscopic property. It is miscible with water and ethanol, slightly soluble in benzene, chloroform and ether.

Toxicity grading

Poisoning

Uses

Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

Acute toxicity

Oral-rat LD50: 5577 mg/kg; Oral-Mouse LD50: 3150 mg/kg.

Category

Toxic substances.

Air & Water Reactions

Hygroscopic. Water soluble.

Uses

As ionizing solvent, manufacture of formic esters, hydrocyanic acid by catalytic dehydration, as softener for paper, animal glues, water-sol gums.

Professional standards

TWA 15 mg/m3; STEL 45 mg/m3

Chemical Properties

Clear, colorless liquid

Acute toxicity

The LD50 for rat via stomach is 6.1g/kg and for mice is 3.15g/kg. Acute symptoms is characterized by the injury of the nervous system, accompanied with conjunctivitis and respiratory disorders, straight convulsions and the final death after 3 to 4 days. The threshold concentration for chronic inhalation effects was 6 ± 4mg/m3. For the maximum allowable concentration for operating environment: for United States, the value is 30 mg/m3 (20 ppm) while the value is 3 mg/m3 (vapor, absorbed through the skin) for Soviet Union.

Reactivity Profile

Formamide is incompatible with strong oxidizers, acids and bases. Sensitive to light. Reacts with water very slowly at room temperature, but rate is accelerated by acids and bases at elevated temperatures. Incompatible with iodine, pyridine and sulfur trioxide. Reacts explosively with furfuryl alcohol, H2O2, Tl(NO3)3.H2O, nitromethane and P2O5. An effective solvent: dissolves casein, glucose, tannins, starch, lignin, polyvinyl alcohol, cellulose acetate, nylon, the chlorides of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel, the acetates of the alkali metals, some inorganic sulfates and nitrates. Attacks copper and brass .
InChI:InChI=1/CH3NO/c2-1-3/h1H,(H2,2,3)

75-12-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1601587)  Residual Solvent Class 2 - Formamide  United States Pharmacopeia (USP) Reference Standard 75-12-7 1601587-3X1.2ML 4,662.45CNY Detail
Sigma-Aldrich (47670)  Formamide  puriss. p.a., ACS reagent, ≥99.5% (GC/T) 75-12-7 47670-2.5L-F 4,303.26CNY Detail
Sigma-Aldrich (47670)  Formamide  puriss. p.a., ACS reagent, ≥99.5% (GC/T) 75-12-7 47670-1L-F 2,939.04CNY Detail
Sigma-Aldrich (47670)  Formamide  puriss. p.a., ACS reagent, ≥99.5% (GC/T) 75-12-7 47670-250ML-F 900.90CNY Detail
Sigma-Aldrich (47670)  Formamide  puriss. p.a., ACS reagent, ≥99.5% (GC/T) 75-12-7 47670-4X25ML-F 912.60CNY Detail
Fluka (34724)  HYDRANAL®-Formamidedry  Solvent for KF titration 75-12-7 34724-6X1L-R 2,850.12CNY Detail
Fluka (34724)  HYDRANAL®-Formamidedry  Solvent for KF titration 75-12-7 34724-1L-R 499.59CNY Detail
Sigma-Aldrich (221198)  Formamide  ACS reagent, ≥99.5% 75-12-7 221198-4X4L 8,061.30CNY Detail
Vetec (V900064)  Formamide  Vetec reagent grade, 98% 75-12-7 V900064-6X500ML 450.45CNY Detail
Vetec (V900064)  Formamide  Vetec reagent grade, 98% 75-12-7 V900064-500ML 90.09CNY Detail
Sigma-Aldrich (295876)  Formamide  spectrophotometric grade, ≥99% 75-12-7 295876-2L 4,210.83CNY Detail
Sigma-Aldrich (295876)  Formamide  spectrophotometric grade, ≥99% 75-12-7 295876-1L 3,100.50CNY Detail

75-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name formamide

1.2 Other means of identification

Product number -
Other names potassium deuteroformate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75-12-7 SDS

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields