75002-98-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-chlorobenzyl bromide is used as a synthetic intermediate for the development of various pharmaceuticals, contributing to the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-6-chlorobenzyl bromide serves as a key intermediate in the synthesis of insecticides and other pesticides, playing a crucial role in the production of effective pest control agents.
Used in Dye and Pigment Production:
This chemical compound is also utilized in the manufacturing of dyes and pigments, where it contributes to the coloration and stability of various products in the textile, paint, and printing industries.
Used in Organic Chemical Synthesis:
Beyond its applications in specific industries, 2-Bromo-6-chlorobenzyl bromide is a versatile building block in organic chemistry, used to synthesize a range of other organic chemicals for diverse applications.
It is important to handle 2-Bromo-6-chlorobenzyl bromide with care due to its potential irritant and toxic properties, ensuring safety measures are in place during its use in research and industrial processes.

Upstream product

• 62356-27-8 2-bromo-6-chlorotoluene 

Downstream Products

• 76574-39-5 2-(2-bromo-6-chlorophenyl)acetonitrile 
• 1393491-73-0 4'-chlorospiro[cyclopentane-1,3'-indolin]-2'-one 
• 1393491-87-6 1-(2-bromo-6-chlorophenyl)cyclopentanecarbonitrile 
• 1596243-33-2 5-chloro-2-phenylquinazoline 
• 1596243-74-1 5-chloro-1,3-dimethyl-2-phenyl-1,2,3,4-tetrahydroquinazoline 

Relevant academic research and scientific papers

DIBENZOHETEROCYCLIC COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

A dibenzoheterocyclic compound wherein band gaps of HOMO and LUMO energy levels of the dibenzoheterocyclic compound are wide, light can be emitted in a deep blue light-emitting region; and the LUMO energy level of the dibenzoheterocyclic compound is low, so the LUMO energy level matches with an electron transport layer for electrons injection and transport. The dibenzoheterocyclic compound has hole transport performance, so as a light-emitting layer material, the dibenzoheterocyclic compound balances the ratio of electrons to holes in a light-emitting layer increasing the combination probability and improving the device light-emitting efficiency. The spatial configuration of the dibenzoheterocyclic compound avoids material stacking molecules, reduces annihilation of excitons, and inhibits efficiency roll-off. The dibenzoheterocyclic compound has thermal stability, so deep blue light can be emitted efficiently and stably. With an organic light-emitting diode and a deep blue light-emitting device with high light-emitting efficiency, low working voltage can be obtained.

A two-benzo heterocyclic compound and its preparation method and application (by machine translation)

The present invention discloses a two-benzo heterocyclic compound, of formula (I) as shown in the structure. Dibenzofluorene and heterocyclic compounds of the LUMO energy level is low, with the electronic transmission material good matching, favorable to electronic injection and transmission. Dibenzofluorene and heterocyclic compound having good hole transmission performance, as luminescent material in the luminescent layer can balance the proportion of electrons and holes, improve the composite probability, make the device light-emitting efficiency is enhanced. Dibenzofluorene and heterocyclic compounds of space configuration can avoid material molecular stacking, and then prevent the intermolecular energy transfer result in high-energy exciton generation, reduce the exciton annihilation, inhibit efficiency roll-off. At the same time, dibenzo heterocyclic compound having good thermal stability, can achieve high-efficiency stable blue-light. The invention also discloses an organic electroluminescent device, at least one functional layer containing the above-mentioned in-diazepine heterocyclic compound, can be obtained with high blue light emitting efficiency and low operating voltage of blue light device. (by machine translation)

TDO2 INHIBITORS

Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

DIFLUOROMETHYLENE COMPOUND

The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles

An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.

Palladium(0)-catalyzed arylative dearomatization of phenols

The palladium-catalyzed arylative dearomatization of phenols to yield spirocyclohexadienone products in good to excellent yields has been developed. Preliminary results demonstrate that the formation of the spirocyclic all-carbon quaternary center can be accomplished with high levels of enantiocontrol (up to 91% ee).

Synthesis of benzocyclobutenes by palladium-catalyzed C-H activation of methyl groups: Method and mechanistic study

An efficient catalytic system has been developed for the synthesis of benzocyclobutenes by C-H activation of methyl groups. The optimal conditions employed a combination of Pd(OAc)2 and PtBu3 as catalyst, K2CO3 as the base, and DMF as solvent. A variety of substituted BCB were obtained under these conditions with yields in the 44-92% range, including molecules that are hardly accessible by other methods. The reaction was found limited to substrates bearing a quaternary benzylic carbon, but benzocyclobutenes bearing a tertiary benzylic carbon could be obtained indirectly from diesters by decarboxylation. Reaction substrates bearing a small substituent para to bromine gave an unexpected regioisomer that likely arose from a 1,4-palladium migration process. The formation of this "abnormal" regioisomer could be suppressed by introducing a larger subsituent para to bromine. DFT(B3PW91) calculations on the reaction of 2-bromo-tert-butylbenzene with Pd(PtBu3) with different bases (acetate, bicarbonate, carbonate) showed the critical influence of the coordination mode of the base to induce both an easy C-H activation and to allow for a pathway for 1,4-palladium migration. Carbonate is shown to be more efficient than the two other bases because it can abstract the proton easily and at the same time maintain κ1-coordination without extensive electronic reorganization.

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.

Halobenzyl ester pesticides

Compounds of the formula STR1 wherein R1 is H or halogen, R2 is halogen, X is H, cyano, ethynyl or thioamido, n is an integer from 1-4 and each Y is H or halogen, are useful as pesticides.