7501-71-5Relevant academic research and scientific papers
Development of drug intermediates by using direct organocatalytic multi-component reactions
Ramachary, Dhevalapally B.,Kishor,Reddy, G. Babul
, p. 1641 - 1646 (2008/02/03)
Development of drug intermediates by using direct amino acid organocatalytic multi-component reaction was investigated. Hydrogenations of double-bond containing compounds including carbonyls, imines and olefins are important for living organisms as well as for the industrial production of chemicals. Amino acid catalysis has emerged as a powerful green synthetic tool for the development of both achiral and chiral catalysis of condensations and cycloadditions and the 1,2- and 1,4-additions of enals, enones and ketones including electrophiles. It was found that the amino acid proline 4a catalyzes the Knoevenagel condenstion of cyclohexanone 1a with the CH-acid ethyl cyanoacetate 2a to furnish the active olefin 9aa. This simple and environmentally friendly approach can be used to construct highly substituted hydrogenated products in a regioselective fashion with good yields.
CARBON-CARBON BOND FORMATION USING MANGANESE(III) ACETATE AS AN ELECTROCHEMICAL MEDIATOR
Shundo, Ryushi,Nishiguchi, Ikuzo,Matsubara, Yoshiharu,Hirashima, Tsuneaki
, p. 831 - 840 (2007/10/02)
Anodic oxidation in a solution containing a variety of olefins and a small amount of Mn(OAc)2*4H2O brought about Mn+3-mediated carbon-carbon bond formation, such as efficient carboxymethylation of styrene derivatives to the corresponding γ-aryl-γ-butyrolactones, and selective coupling of active methylene compounds with non-activated monoolefins, unconjugated dienes or 5-arylpent-1-enes.
Selective Coupling of Non-Activated Olefins with Ethyl Cyanoacetate by Mn(3+)-Mediated Anodic Oxidation
Shundo, Ryushi,Nishiguchi, Ikuzo,Matsubara, Yoshiharu,Hirashima, Tsuneaki
, p. 2285 - 2288 (2007/10/02)
Novel carbon-carbon bond formation of non-activated olefins with ethyl cyanoacetate has been developed by anodic oxidation using only small amount of Mn(OAc)2*4H2O to give selectively either saturated or unsaturated coupling products depending upon the pr
REACTIVITY OF CYCLOALKENES IN THE RADICAL ADDITION REACTION WITH ETHYL CYANOACETATE
Hajek, Milan,Malek, Jaroslav
, p. 1940 - 1949 (2007/10/02)
The effect of ring size on the reactivity of C5 to C12 cycloalkenes in the copper(II) oxide catalysed and dibenzoyl peroxide initiated addition reaction with ethyl cyanoacetate was determined at 90 deg C using the method of competition reactions. cis-Cycl
