75014-25-4 Usage
Uses
Used in Pharmaceutical Industry:
(S)-(-)-N-<4-<3-<(1,1-dimethylethyl)amino>-2-hydroxypropoxy>-1,2,5-thiadiazol-3-yl>-N-(2-hydroxyethyl)glycine is used as an impurity in the synthesis and production of Timolol (T443695), an antihypertensive agent. Its presence in the manufacturing process is crucial for ensuring the quality and safety of the final drug product. Timolol is used to increase ocular blood flow and reduce intraocular pressure, making it a valuable treatment for glaucoma and other eye conditions.
Additionally, as an impurity of Timolol, (S)-(-)-N-<4-<3-<(1,1-dimethylethyl)amino>-2-hydroxypropoxy>-1,2,5-thiadiazol-3-yl>-N-(2-hydroxyethyl)glycine may also be relevant in research and development efforts aimed at understanding the properties and effects of Timolol and its related compounds. This can contribute to the advancement of pharmaceutical science and the development of new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 75014-25-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,0,1 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 75014-25:
(7*7)+(6*5)+(5*0)+(4*1)+(3*4)+(2*2)+(1*5)=104
104 % 10 = 4
So 75014-25-4 is a valid CAS Registry Number.
75014-25-4Relevant academic research and scientific papers
Urinary Metabolites of Timolol from Humans and Laboratory Animals. Syntheses and β-Adrenergic Blocking Activities
Wasson, B. K.,Scheigetz, J.,Rooney, C. S.,Hall, R. A.,Share, N. N.,et al.
, p. 1178 - 1184 (2007/10/02)
Syntheses are reported for three metabolites (2-4) of timolol (1) formed by oxidative metabolism of the morpholine ring.GLC-MS comparisons are presented which establish that the two metabolites whose structures were previously in question are identical with their synthetic counterparts 2 and 3.In 2, metabolic oxidation of the 4-morpholinyl group of 1 has occurred at the carbon next to oxygen to give the 2-hydroxy-4-morpholinyl moiety, whereas in 3, the morpholine of 1 has been oxidized one step further and then ring opened to produce the N-(2-hydroxyethyl)glycine substituent.Biological testing of synthetic samples of the three major metabolites from human urine (3, 4, and 6) indicated that only 4, in which the morpholine moiety has been degraded to a 2-hydroxyethylamino group, had significant β-adrenergic blocking activity (one-seventh that of timolol in anesthetized dogs).
