75014-26-5 Usage
Uses
Used in Pharmaceutical Industry:
(S)-(-)-1-<(1,1-dimethylethyl)amino>-3-<<4-<(2-hydroxyethyl)amino>-1,2,5-thiadiazol-3-yl>oxy>-2-propanol is used as an impurity in the production of Timolol, an antihypertensive agent. It plays a role in increasing ocular blood flow and reducing intraocular pressure, which can be beneficial for treating conditions such as glaucoma and ocular hypertension.
Used in Research and Development:
(S)-(-)-1-<(1,1-dimethylethyl)amino>-3-<<4-<(2-hydroxyethyl)amino>-1,2,5-thiadiazol-3-yl>oxy>-2-propanol can be used as a research compound for studying the properties and potential applications of Timolol and its derivatives. This may include investigating its pharmacological effects, mechanisms of action, and potential synergistic or antagonistic interactions with other compounds.
Used in Quality Control and Analysis:
(S)-(-)-1-<(1,1-dimethylethyl)amino>-3-<<4-<(2-hydroxyethyl)amino>-1,2,5-thiadiazol-3-yl>oxy>-2-propanol can be utilized in quality control processes to ensure the purity and efficacy of Timolol and its formulations. Analytical techniques such as chromatography, mass spectrometry, and spectroscopy can be employed to detect and quantify the presence of this impurity in pharmaceutical products.
Used in Drug Development and Optimization:
(S)-(-)-1-<(1,1-dimethylethyl)amino>-3-<<4-<(2-hydroxyethyl)amino>-1,2,5-thiadiazol-3-yl>oxy>-2-propanol may serve as a starting point or intermediate in the development of new drugs with similar or improved therapeutic properties compared to Timolol. Researchers can explore modifications to its molecular structure to enhance its pharmacological effects, bioavailability, or safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 75014-26-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,0,1 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 75014-26:
(7*7)+(6*5)+(5*0)+(4*1)+(3*4)+(2*2)+(1*6)=105
105 % 10 = 5
So 75014-26-5 is a valid CAS Registry Number.
75014-26-5Relevant academic research and scientific papers
Wasson, B. K.,Scheigetz, J.,Rooney, C. S.,Hall, R. A.,Share, N. N.,et al.
, p. 1178 - 1184 (1980)
Syntheses are reported for three metabolites (2-4) of timolol (1) formed by oxidative metabolism of the morpholine ring.GLC-MS comparisons are presented which establish that the two metabolites whose structures were previously in question are identical with their synthetic counterparts 2 and 3.In 2, metabolic oxidation of the 4-morpholinyl group of 1 has occurred at the carbon next to oxygen to give the 2-hydroxy-4-morpholinyl moiety, whereas in 3, the morpholine of 1 has been oxidized one step further and then ring opened to produce the N-(2-hydroxyethyl)glycine substituent.Biological testing of synthetic samples of the three major metabolites from human urine (3, 4, and 6) indicated that only 4, in which the morpholine moiety has been degraded to a 2-hydroxyethylamino group, had significant β-adrenergic blocking activity (one-seventh that of timolol in anesthetized dogs).
