7504-94-1

Basic information

• Product Name: 2(1H)-Pyrimidinone, hydrazone (9CI)
• Synonyms: 2(1H)-Pyrimidinone, hydrazone (9CI);1-(2-Pyrimidinyl)hydrazine;1-(Pyrimidine-2-yl)hydrazine;2(1H)-Pyrimidinone hydrazone;2-Hydrazono-2,3-dihydropyrimidine;2-Pyrimidinylhydrazine;2-hydrazinopyrimidine(SALTDATA: FREE);2-HydrazinylpyriMidine
• CAS NO: 7504-94-1
• Molecular Formula: C₄H₆N₄
• Molecular Weight: 110.11724
• EINECS: 1592732-453-0
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 7504-94-1.mol
• Article Data: 26

Chemical Properties

• Melting Point: 86-88 °C(Solv: benzene (71-43-2))
• Boiling Point: 291.3 °C at 760 mmHg
• Flash Point: 130 °C
• Appearance: /
• Density: 1.334 g/cm³
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 6.17±0.20(Predicted)
• CAS DataBase Reference: 2(1H)-Pyrimidinone, hydrazone (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, hydrazone (9CI)(7504-94-1)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, hydrazone (9CI)(7504-94-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 7504-94-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H6N4/c5-8-4-6-2-1-3-7-4/h1-3H,5H2,(H,6,7,8)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 302-01-2 hydrazine 
• 931-63-5 2-methoxypyrimidine 

Downstream Products

• 205443-44-3 2,6-di-tert-butyl-4-(pyrimidin-2-ylhydrazonomethyl)phenol 
• 258824-32-7 3-[4-(3-chloro-phenyl)-piperazin-1-yl]-1-(5-phenyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one 
• 863650-90-2 benzyl {(1S)-2-phenyl-1-[1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]ethyl}carbamate 
• 1034280-71-1 4-(3-bromo-4-chlorophenyl)-2-pyrimidin-2-yl-5-(trifluoromethyl)-2H-pyrazol-3-ylamine 
• 1034283-91-4 4-(4-bromophenyl)-3-(dimethoxymethyl)-1-pyrimidin-2-yl-1H-pyrazole-5-amine 
• 1270083-90-3 3-(4-iodophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-ol 
• 65267-35-8 N-benzylidene-N'-pyrimidin-2-ylhydrazine 
• 58953-43-8 N-(p-chlorobenzylidene)-N'-pyrimidin-2-ylhydrazine 
• 732277-68-8 1-{6-[(4-nitrophenyl)-(pyrimidin-2-yl-hydrazono)-methyl]-benzo-1,3-dioxol-5-yl}-propan-2-ol 
• 89978-00-7 5-amino-1-pyrimidin-2-yl-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

Synthesis, crystal structures, and magnetic properties of methoxido-bridged dinuclear MnIII complexes derived from tri-dentate chelating ligands

Two new doubly methoxido-bridged MnIII dinuclear complexes, [MnIII(mphp)(μ-OCH3)(CH3OH)]2·2CH3OH (1) and ([MnIII(ahbz)(μ-OCH3)(CH3OH)]2·2CH3

Tetrahydroindazole inhibitors of CDK2/cyclin complexes

Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogues 53 and 59 showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogues to a CDK2/cyclin complex is favored over binding to free CDK2. Computational analysis was used to predict a potential binding site at the CDK2/cyclin E1 interface.

NNO type quinoline Fe (II) complex containing multiple coordination sites as well as preparation method and application of NNO type quinoline Fe (II) complex

The invention discloses an NNO type quinoline Fe (II) complex containing multiple coordination sites as well as a preparation method and application of the NNO type quinoline Fe (II) complex. The complex is a quinoline-2-formaldehyde-benzoyl hydrazone Fe