75040-47-0

Upstream product

• 64-17-5 ethanol 
• 65706-44-7 tert-butyl 3-(3-(bromomethyl)phenyl)propanoate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 540-88-5 acetic acid tert-butyl ester 
• 108-18-9 diisopropylamine 
• 626-15-3 1,3-bis-(bromomethyl)benzene 

Downstream Products

• 65706-16-3 3-[3-(2-Ethoxycarbonyl-ethyl)-phenyl]-2-(3-oxo-octylamino)-propionic acid ethyl ester 
• 65706-37-8 3-[3-(2-Ethoxycarbonyl-ethyl)-phenyl]-2-(3-hydroxy-octylamino)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Nitrogen heterocycles

Hydantoins of formula (I) STR1 ps have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis.

Heterocyclic Prostaglandin Analogues. Part 2. Hydantoins and Other Imidazole Analogues

The stable hydantoin prostaglandin analogues (2b) and (3b) have been synthesised as racemic compounds.The less polar diastereoisomer of (2b) is a potent inhibitor of platelet aggregation in human platelet-rich plasma and its cyclohexyl analogue (22, R = C6H11) has ca. 14 times the potency of prostaglandin E1 in this test coupled with selectivity of biological action.Other structural modifications such as introduction of a 15-methyl group and insertion of the m-phenylene or m-oxaphenylene moieties into the acid side-chain of (2b) led to a reduction in anti-aggregatory potency.Synthesis of the imidazole (41) is described.

Nitrogen heterocycles

Hydantoins and N-alkylhydantoins of formula (I) STR1 have biological properties related to those of naturally occurring prostaglandins and maybe used in medicine, for example in the treatment of thrombosis.