7505-84-2Relevant academic research and scientific papers
Synthesis of 3,3′-Disubstituted Isobenzofuran-1(3H)-Ones via Cs0.5H2.5PW12O40-Catalyzed Difunctionalization of Carbonyls
Liu, Yu-Feng,Cao, Gang-Ming,Chen, Lei,Li, Ke,Lin, Xiao-Ling,Xu, Xin-Xin,Le, Zhang-Gao,Yang, Guo-Ping
, p. 1460 - 1464 (2022/03/31)
We reported a method for the synthesis of 3,3′-disubstituted isobenzofuran-1(3H)-ones via the carbonyl difunctionalization of 2-acylbenzoic acids. A range of nucleophiles was reacted with 2-acylbenzoic acids to furnish the functionalized isobenzofuran-1(3H)-ones with the factual yield range of 61–96%. The reaction uses Cs0.5H2.5PW12O40 as a catalyst and produces water as the sole by-product. Various functional groups could be introduced to the isobenzofuran-1(3H)-one skeletons via the C?P/C?N/C?O/C?C bond formation, which would provide opportunities for the synthesis of potential biologically active molecules. Based on the preliminary experiments, a plausible mechanism is proposed. (Figure presented.).
Preparation of 3-Hydroxyindolin-1-ones and o-Acylbenzamides. A Study of Ring-Chain Tautomerism
Nishio, Takehiko,Yamamoto, Hiroshi
, p. 883 - 892 (2007/10/02)
3-Hydroxyisoindolinones (ring form) as well as their chain tautomers, o-acylbenzamides, were prepared from the reactions of 3-benzalphthalide 1, 3-halophthalides 3, and o-acylbenzoic acids 6 or their esters 7 with amines 2, and those of phthalimides 4 wit
