75052-58-3Relevant articles and documents
Method and catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives
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Paragraph 0043; 0044; 0045, (2017/07/20)
The invention discloses a method and a catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives, and belongs to the technical field of organic chemical industry. Magnetic material loaded alkaline ionic liquid is used as the catalyst, a molar ratio of aromatic aldehyde to active methylene compounds to methyl thioglycolate in preparation reaction is 2:(2-2.5):1, the molar weight, which is computed on the basis of alkaline ionic liquid on load, of the magnetic material loaded alkaline ionic liquid, which is the catalyst, is 8-12% of the molar weight of the methyl thioglycolate, and the reflux reaction time is 17-67 min. Compared with other preparation methods, the method and the catalyst have the advantages that the catalyst is low in loss during recycling and is high in recyclable times and product selectivity, integral preparation procedures are simple, convenient and economical, and accordingly industrial large-scale production can be facilitated.
Studies on thiazolopyridines. Part 1: Antimicrobial activity of some novel fluorinated thiazolo[3,2-a]pyridines and thiazolo[2′,3′:1,6]pyrido[2,3-d]pyrimidines
El-Maghraby, Ahmed A.,Ali, Gameel A. M. El-Hag,Ahmed, Ahmed H. A.,El-Gaby, Mohamed S. A.
, p. 293 - 302 (2007/10/03)
Ternary condensation of aromatic aldehydes, malononitrile and thioglycolic acid (2:2:1 molar ratio) in ethanol/piperidine afforded the corresponding thiazolo[3,2-a]pyridines 1a-d. Thiazolo/2′,3′:1,6]-pyrido[2,3-d]pyrimidine 4 was obtained by refluxing of compound 1a with acetic anhydride. Also, thiazolopyrido pyrimidine 6 was produced by refluxing of 1a with triethylorthoformate followed by treatment with hydrazine hydrate. Refluxing 1a with formic acid yielded the thiazolopyridopyrimidine 8 which on chlorination with thionyl chloride furnished the chloro derivative 9. Finally, amino thiazolo[2′,3′:1,6]pyrido[2,3-d]pyrimidine 10 was obtained by treatment of 1a with formamide. The structures of these compounds were established on the basis of elemental analyses, IR, 1H NMR, and mass spectral data. Also, the antimicrobial activity of some synthesized compounds is reported.
Synthetic Studies Using α,β-Unsaturated Nitriles: Facile Synthesis of Pyridine Derivatives
Kambe, Satoshi,Saito, Koji,Sakurai, Akio,Midorikawa, Hiroshi
, p. 531 - 533 (2007/10/02)
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