75057-31-7

Basic information

• Product Name: 3,4-diacetyl-5-methyl-1-phenyl-1H-pyrazole
• Synonyms: 3,4-diacetyl-5-methyl-1-phenyl-1H-pyrazole
• CAS NO: 75057-31-7
• Molecular Weight: 242.277
• Mol File: 75057-31-7.mol

Chemical Properties

• CAS DataBase Reference: 3,4-diacetyl-5-methyl-1-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diacetyl-5-methyl-1-phenyl-1H-pyrazole(75057-31-7)
• EPA Substance Registry System: 3,4-diacetyl-5-methyl-1-phenyl-1H-pyrazole(75057-31-7)

Safety Data

• Hazardous Substances Data: 75057-31-7(Hazardous Substances Data)

Upstream product

• 18440-58-9 1-(N-phenylhydrazono)-1-chloropropanone 
• 123-54-6 acetylacetone 
• 62-53-3 aniline 
• 74519-41-8 C₉H₉BrN₂O 

Downstream Products

• 1335118-55-2 4,7-bis[(2-oxo-1-phenylhydrazono)-3-methyl-2-phenyl-ethyl]-2H-pyrazolo[3,4-d]pyridazine 
• 1364309-63-6 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(3-(furan-2-yl)prop-2-en-1-one) 
• 1364309-60-3 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(3-(4-chlorophenyl)prop-2-en-1-one) 
• 1364309-54-5 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(3-phenylprop-2-en-1-one) 
• 1364309-57-8 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(3-(4-methoxyphenyl)prop-2-en-1-one) 
• 1335118-59-6 C₂₀H₂₄N₄O₂ 
• 1445657-35-1 4,7-bis-(3-acetyl-1-phenyl-1H-pyrazol-4-yl)-3-methyl-2-phenyl-2H-pyrazolo[3,4-d]pyridazine 
• 1445657-16-8 C₂₀H₂₄N₆ 

Relevant articles and documents

Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors

A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.

Convenient Synthesis of Polyaza-3,4-bis(heteroaryl)pyrazoles

GRAPHICAL ABSTRACT Reactions of a new series of bis-enaminones with some N- and C-nucleophiles proved to be convenient routes for syntheses of a variety of novel 3,4-bis(heteroaryl)pyrazoles. The structures of the compounds were elucidated on the basis of

Reaction of hydrazonoyl halides with bis-enaminones: A convenient route for synthesis of novel polyaza-terheterocycles

New bis(pyrazolylenaminones) were prepared in good yields. Their synthetic utilities as precursors for regioselective synthesis of novel bis(hetarylpyrazoles) were also investigated. The mechanisms and selectivities observed in the studied reactions were

Synthesis and biological evaluation of some N-arylpyrazoles and pyrazolo[3,4-d]pyridazines as anti-inflammatory agents

A series of 3,4-bis-chalcone-N-arylpyrazoles 3a-k was prepared from diacetyl pyrazoles 2a-e. The reaction of 2d and 2e with hydrazine hydrate gave pyrazolo[3,4-d]pyridazine derivatives 4a-b. Furthermore, the reaction of 2a-e with thiosemicarbazide afforde

Microwave-assisted synthesis of novel 3,4-Bis-chalcone-N-arylpyrazoles and their anti-inflammatory activity

A series of 3,4-bis-chalcone-N-arylpyrazoles 3a-h was prepared conveniently from diacetyl pyrazoles 2a,b. All reactions were carried out under conventional thermal heating and/or microwave irradiation. The structure of the latter functionally pyrazoles wa

Studies on Nitrile Imines : Synthesis of Pyrazoles Using Active Methylene Compounds

A series of C-ethoxycarbonyl and C-acetyl derivatives of hydrazidoyl halides have been prepared and reacted with carbanions of active methylene compounds to afford substituted pyrazoles (II and III) in good yields.The formation of pyrazoles involves the alkylation of active methylene group by hydrazidoyl halides to give the acyclic hydrazones, which then undergo cyclization to give the corresponding pyrazoles.The structural assignments of the products are based on spectral and chemical evidences.