750588-65-9Relevant academic research and scientific papers
Studies towards the synthesis of superstolide A: An aldol-based construction of an advanced C1-C5/C20-C26 segment
Paterson, Ian,Mackay, Angela C.
, p. 1359 - 1362 (2004)
Based on a boron-mediated syn aldol reaction of an alanine-derived ethyl ketone with an α-chiral aldehyde partner, an advanced intermediate for superstolide A was assembled in a highly stereocontrolled fashion. Controlled 1,3-anti reduction of the resulting β-hydroxy ketone gave the characteristic amino diol stereopentad of superstolide, followed by a Takai olefination and esterification of the C23 hydroxyl to provide the elaborated C1-C5/ C20-C26 segment 3.
