750596-77-1

Upstream product

• 75633-62-4 (1R,2R)-2-(benzyloxycarbonylamino)cyclohexane carboxylic acid 
• 7107-58-6 benzyl N-cyclohexylcarbamate 
• 909906-82-7 C₁₅H₂₁NO₃ 
• 36278-22-5 1-cyclohexenoyl chloride 
• 101033-15-2 1-cyclohexene-1-carbonyl azide 
• 5041-27-0 1-isocyanatocyclohex-1-ene 
• 100-51-6 benzyl alcohol 

Downstream Products

• 106942-31-8 (αR,1S)-ethyl α-hydroxy-2-oxocyclohexaneacetate 
• 750596-85-1 (1S)-hydroxy-(2-oxo-cyclohexyl)-acetic acid ethyl ester 
• 750596-85-1 (1S)-hydroxy-(2-oxo-cyclohexyl)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Photoredox/Cobalt Dual-Catalyzed Decarboxylative Elimination of Carboxylic Acids: Development and Mechanistic Insight

Recently, dual-catalytic strategies towards the decarboxylative elimination of carboxylic acids have gained attention. Our lab previously reported a photoredox/cobaloxime dual catalytic method that allows the synthesis of enamides and enecarbamates directly from N-acyl amino acids and avoids the use of any stoichiometric reagents. Further development, detailed herein, has improved upon this transformation's utility and further experimentation has provided new insights into the reaction mechanism. These new developments and insights are anticipated to aid in the expansion of photoredox/cobalt dual-catalytic systems.

A mild and convenient synthesis of N-carbobenzyloxy ketimines

N-Carbobenzyloxy (Cbz) ketimines were prepared conveniently from N-Cbz amines by oxidation with N-tert-butylbenzenesulfinimidoyl chloride. The Royal Society of Chemistry 2006.

Highly diastereo- and enantioselective reactions of enecarbamates with ethyl glyoxylate to give optically active syn and anti α-alkyl-β- hydroxy imines and ketones

The remarkably selective addition of enecarbamates 2 to ethyl glyoxylate (1) in the presence of a copper-dilmine catalyst (0.1 mol%) gives the corresponding imines 3 in high yields with excellent enantioselectivities. A concerted aza-enetype reaction mech

Highly diastereo- and enantioselective reactions of enecarbamates with an aldehyde

Catalytic asymmetric addition reactions of enecarbamates with ethyl glyoxylate have been developed using CuClO4·4CH3CN and a diimine ligand as the catalyst. Highly diastereo- and enantioselective addition reactions of α-mono-substitu