7506-25-4

Usage

Structure

Cyclohexane ring with two side chains attached

Side chain 1

Contains a dione group (4,4-dimethyl-2,6-dioxo-cyclohexyl)

Side chain 2

Contains a hydroxy and methoxy substituted phenyl group (4-hydroxy-3-methoxy-phenyl)

Substituents

Both methyl and dimethyl groups present

Potential applications

Pharmaceuticals, potential bioactivity

Complexity

Due to the structure and substituents, further research is needed to fully understand its properties and potential uses.

Upstream product

• 126-81-8 dimedone 
• 121-33-5 vanillin 

Downstream Products

• 1234212-93-1 9-(4-hydroxy-3-methoxyphenyl)-3,3,6,6-tetramethyl-10-thioctinoylamino-3,4,6,7,9,10-hexahydro-1,8(2H,5H)acridinedione 
• 442651-96-9 9-(4-hydroxy-3-methoxyphenyl)-3,3,6,6,10-pentamethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione 
• 331711-19-4 9-(4-acetoxy-3-methoxy-phenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione 
• 30038-65-4 9-(4-hydroxy-3-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione 

Relevant academic research and scientific papers

Merging supramolecular catalysis and aminocatalysis: Amino-appended β-cyclodextrins (ACDs) as efficient and recyclable supramolecular catalysts for the synthesis of tetraketones

Well-designed amino-appended β-cyclodextrins (ACDs) with an amino side chain of different lengths at the primary face of β-CD were synthesized and employed in the catalytic synthesis of a series of tetraketones as supramolecular catalysts in water for the first time. Yields of 58-97% were obtained with up to 30 examples of substrate. The catalyst could be recycled easily, while a 92% yield and 84% rate of catalyst recovery could be achieved after 8 cycles of catalyst recycling. Moreover, a catalytic mechanism merging supramolecular catalysis and aminocatalysis could be proposed through detailed 1D and 2D NMR, ESI-MS and Job plot analyses. This protocol retained the promising characteristics of ambient temperature, green medium, simple operation, broad substrate scope, excellent yields, superb catalyst recycling performance and unique catalytic mechanism.

ACRIDINEDIONE DERIVATIVES FOR TREATING PIGMENTATION DISORDERS AND AGEING OF THE SKIN

The present invention relates to a compound of general formula (I) in which: —R1 and R2 are simultaneously or independently H, OH, OCH3 or a C1-C5 alkyl radical, —R3 and R4 are s

An efficient and simple synthesis of tetraketones catalyzed by Yb(OTf) 3-sio2 under solvent free conditions

A novel and efficient three-component one-pot condensation method has been described for the synthesis of tetraketones or arylmethylene[bis(3-hydroxy-2- cyclohexene-1-ones)] using Yb(OTf)3-SiO2 and amine as catalytic system under sol

Molecular folding induced nanogold aggregation

Bisacridinedione-functionalized gold nanoparticles (bisADD-GNPs) were prepared and characterized. BisADD is a flexible acyclic moiety and a specific Ca2+ sensor. Signaling of the binding events is achieved by the cation-induced folding of the bisADD-GNPs and the resultant fluorescence enhancement and visual color change are attributed to the suppression of photoinduced electron transfer (PET) through space and nano-Au aggregation. The selective binding of Ca2+ is clear from steady state fluorescence and TEM techniques.

Specific ca2+ fluorescent sensor: Signaling by conformationally induced pet suppression in a bichromophoric acridinedione

A series of acridinedione-based bichromophoric podand systems 1a-c were synthesized and characterized. Among these, bichromophore 1c shows specific binding of Ca2+ in the presence of other biologically important metal ions like Na+, K+, Mg2+, and Zn2+, The selective complexation was proved by steady-state emission, time-resolved emission, and 1H NMR titration. Signaling of the binding event was achieved by Ca2+-induced folding of the bichromophore, resulting in PET suppression in the acridinedione chromophore. Involvement of a PET process in the optical signaling was confirmed by comparing bichromophores 1a-c with non-PET compound 2 -and monochromophore model compound 3. Non-PET compound 2 failed to give optical response upon Ca2+ binding as a result of the absence of a POT process in the Ca2+-bound complex. Monochromophore 3 shows a similar optical response, which is the same as that in 1c. Titration of the metalion-bound complex of 1c with EDTA released the metal ion from the complex, thereby regaining the original photophysical properties of the bichromophore.

Tetraketones: A new class of tyrosinase inhibitors

Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC 50 = 2.61 μM), and 27 (ICsu