750633-66-0

Basic information

• Product Name: 3-BROMO-3'-METHOXYBENZOPHENONE
• Synonyms: 3-BROMO-3'-METHOXYBENZOPHENONE
• CAS NO: 750633-66-0
• Molecular Formula: C₁₄H₁₁BrO₂
• Molecular Weight: 291.14
• Mol File: 750633-66-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 405.1°C at 760 mmHg
• Flash Point: 198.8°C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 8.97E-07mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 3-BROMO-3'-METHOXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-3'-METHOXYBENZOPHENONE(750633-66-0)
• EPA Substance Registry System: 3-BROMO-3'-METHOXYBENZOPHENONE(750633-66-0)

Safety Data

• Hazardous Substances Data: 750633-66-0(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of 3-bromobenzoyl chloride with 3-methoxyphenylmagnesium –bromide.

InChI:InChI=1/C14H11BrO2/c1-17-13-7-3-5-11(9-13)14(16)10-4-2-6-12(15)8-10/h2-9H,1H3

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 207681-67-2 N-methoxy-N-methyl-3-bromobenzamide 
• 76778-33-1 3-bromo-α-(3-methoxyphenyl)benzenemethanol 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 750633-59-1 3-(3-methoxybenzoyl)benzonitrile 
• 1357563-32-6 (4'-hydroxy-3'-methylbiphenyl-3-yl)-(3-hydroxyphenyl)-methanone 
• 1357563-58-6 (4'-methoxy-3'-methyl-[1,1'-biphenyl]-3-yl)(3-methoxyphenyl)methanone 
• 62810-50-8 (3-bromophenyl)-(3-hydroxyphenyl)methanone 
• 946830-92-8 3'-cyano-3-methoxybenzophenone 4-methylphenylsulfonylhydrazone 
• 937375-33-2 5-(3-bromo-phenyl)-5-(3-methoxyphenyl)-imidazolidine-2,4-dione 
• 908368-75-2 (R)-3-(3,7-dimethyloctyl)-3'-methoxybenzophenone 

Relevant articles and documents

An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme (Cathepsin L) currently in preclinical trials for the treatment of metastatic cancer, which is a leading cause of cancer-associated death. Herein, we report two new synthetic routes for synthesizing the target compound through four consecutive steps, using a Weinreb amide approach starting from a common 3-bromobenzoyl chloride. A key step in the approach is a coupling reaction of a readily available Grignard reagent with amide 4 to produce 6, a previously unreported coupling pattern. These new strategies offer an efficient and alternative approach to synthesis of target compound with an excellent overall yield.

Palladium-catalyzed C-H activation/intramolecular amination reaction: A new route to 3-aryl/alkylindazoles

A method for the catalytic C-H activation of hydrazone compounds followed by intramolecular amination is described. It requires the use of a catalytic amount of Pd(OAc)2 in the presence of Cu(OAc)2 and AgOCOCF3, which effi