750641-60-2Relevant articles and documents
Enantiocomplementary Total Asymmetric Syntheses of Prostaglandin A2
Newton, Roger F.,Reynolds, Derek P.,Davies, John,Kay, Paul B.,Roberts, Stanley M,Wallace, Timothy W.
, p. 683 - 686 (2007/10/02)
Both enantiomers of the racemic ketone (4) have been converted into (+)-PGA2 by utilizing two different synthetic pathways.In one route the reaction of the strained tricyclic ketone (8) with the cuprate reagent (9) was the critical step, while in the ' enantiocomplementary ' process the SN' reaction of the same cuprate reagent with the epoxide (16) was the crucial transformation.