75073-11-9

Basic information

• Product Name: 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE
• Synonyms: 2-AMINO-5-IODO-6-METHYLPYRIDINE;AKOS BB-8251;5-IODO-6-METHYLPYRIDIN-2-AMINE;5-IODO-6-METHYL-PYRIDIN-2-YLAMINE;5-IODO-6-METHYL-2-PYRIDINAMINE;6-AMINO-3-IODO-2-PICOLINE;ASISCHEM X26971;VITAS-BB TBB000516
• CAS NO: 75073-11-9
• Molecular Formula: C₆H₇IN₂
• Molecular Weight: 234.04
• Product Categories: Pyridine;Boronic Acid;Pyridines;Amino-pyridine series;Heterocycle-Pyridine series
• Mol File: 75073-11-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 99.9-100.1°C
• Boiling Point: 287 °C at 760 mmHg
• Flash Point: 127.4 °C
• Appearance: /
• Density: 1.898
• Vapor Pressure: 0.00255mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE(75073-11-9)
• EPA Substance Registry System: 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE(75073-11-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 75073-11-9(Hazardous Substances Data)

Usage

General Description

5-IODO-6-METHYL-PYRIDIN-2-YLAMINE, also known as 5-Iodo-6-methylpyridin-2-ylamine, is a chemical compound with the molecular formula C6H7IN2. It is a derivative of pyridine and contains an amino group attached to the second carbon atom of the pyridine ring. 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological properties, including its antimicrobial and anticancer activities. Additionally, it is used in the development of organic light-emitting diodes (OLEDs) and as a reagent in organic synthesis. Overall, 5-IODO-6-METHYL-PYRIDIN-2-YLAMINE has significant applications in the fields of chemistry, pharmaceuticals, and materials science.

InChI:InChI=1/C6H7IN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 361533-42-8 diethyl 2-{[(5-iodo-6-methyl-2-pyridinyl)amino]methylene}malonate 
• 909711-82-6 6-methyl-5-(methylthio)pyridin-2-amine 
• 1575836-93-9 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate 
• 1575836-90-6 tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate 
• 1575831-00-3 1-(2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-yl)-2-(methylsulfonyl)ethanone 

Relevant articles and documents

Encoding Multiple Reactivity Modes within a Single Synthetic-Replicator

Establishing programmable and self-sustaining replication networks in pools of chemical reagents is a key challenge in systems chemistry. Self-replicating templates are formed from two constituent components with complementary recognition and reactive sites via a slow bimolecular pathway and a fast template-directed pathway. Here, we re-engineer one of the components of a synthetic replicator to encode an additional recognition function, permitting the assembly of a binary complex between the components that mediates replicator formation through a template-independent pathway, which achieves maximum rate acceleration at early time points in the replication process. The complementarity between recognition sites creates a key conformational equilibrium between the catalytically inert product, formed via the template-independent pathway, and the catalytically active replicator that mediates the template-directed pathway. Consequently, the rapid formation of the catalytically inert isomer kick-starts replication through the template-directed pathway. Through kinetic analyses, we demonstrate that the presence of the two recognition-mediated reactivity modes results in enhanced template formation in comparison to that of systems capable of exploiting only a single recognition-mediated pathway. Finally, kinetic simulations reveal that the conformational equilibrium and both the relative and absolute efficiencies of the recognition-mediated pathways affect the extent to which self-replicating systems can benefit from this additional template-independent reactivity mode. These results allow us to formulate the rules that govern the coupling of replication processes to alternative recognition-mediated reactivity modes. The interplay between template-directed and template-independent pathways for replicator formation has significant relevance to ongoing efforts to design programmable and adaptable replicator networks.

HETEROCYCLIC COMPOUND

Provided is a compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and is useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.