75076-12-9

Upstream product

• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 15764-16-6 2,4-dimethylbenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1417627-75-8 3-(2,4-dimethylphenyl)-1,6-dimethyl-2,3-dihydroquinoline-4,4(1H)-dicarbonitrile 
• 1417627-93-0 2-(2-((4-(tert-butyl)phenyl)(methyl)amino)-1-(2,4-dimethylphenyl)ethyl)malononitrile 
• 1417627-80-5 6-(tert-butyl)-3-(2,4-dimethylphenyl)-1-methyl-2,3-dihydroquinoline-4,4(1H)-dicarbonitrile 

Relevant academic research and scientific papers

Facile synthesis of pure non-monoclinic zirconia nanoparticles and their catalytic activity investigations for Knoevenagel condensation

Zirconia nanoparticles were synthesized by the non-hydrolytic thermal decomposition of zirconyl chloride octahydrate in the presence of oleylamine and oleic acid. The nanoparticles were characterized by XRD, HR-TEM and EDAX techniques. TEM observation con

Molybdenum carbide as an efficient and durable catalyst for aqueous Knoevenagel condensation

By following green chemistry principles, various molybdenum compounds as cost-effective, commercially available, heterogeneous, and benign catalysts were used for the Knoevenagel condensation reaction. Among the compounds (Mo2C, MoS2, MoB, MoSi2), molybdenum carbide showed efficient performance for the Knoevenagel condensation in aqueous media at room temperature, affording the corresponding products in high yields within a short reaction time. Notably, using this commercially available heterogeneous catalyst, the deacetalization-Knoevenagel condensation of benzaldehyde dimethyl acetal and malononitrile at room temperature could successfully proceed in excellent yield. Molybdenum carbide could be recovered five times without loss of activity with an operationally simple procedure.

Bis-functionalization of 1,3-dienes through 1,4-conjugate addition of amphiphilic bis-π-allyl and related palladium intermediates

Palladium-catalyzed three-component coupling of allylstannane, allyl chloride and a functionalized diene is described. Regioselective 1,4-functionalization of the Michael acceptor 1,3-diene is accomplished by the amphiphilic bis-π-allylpalladium complex.

Pyridine and pyrimidine derivatives

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and X are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment