75082-00-7Relevant academic research and scientific papers
Design of mesoporous aluminosilicates supported (1R,2S)-(-)-ephedrine: Evidence for the main factors influencing catalytic activity in the enantioselective alkylation of benzaldehyde with diethylzinc
Abramson,Lasperas,Brunel
, p. 357 - 367 (2007/10/03)
(-)-Ephedrine, used as a model β-amino alcohol, was covalently anchored on mesoporous micelle templated aluminosilicates (Al-MTS) through nucleophilic substitution of halogenoalkyl(aryl)silane chains previously grafted on the surface. The covalent graftin
Nitriles under palladium-catalyzed hydrogenation conditions as substitutes for aldehydes in the reaction with 1,2-amino alcohols: Formation of 1,3-oxazolidines and reductive N-alkylation
Henin, Francoise,Letinois, Stephane,Muzart, Jacques
, p. 7187 - 7190 (2007/10/03)
At room temperature, the presence of hydrogen and catalytic amounts of Pd/C induced the formation of 1,3-oxazolidines from nitriles and 1,2-amino alcohols. The subsequent reductive cleavage of the NC-O bond of these heterocycles occurred under the same conditions. Thus, this methodology provides a new one-pot N-alkylation of 19-amino alcohols using nitriles as reagents with yields up to 98%.
