75088-83-4Relevant academic research and scientific papers
MANOALIDE, AN ANTIBIOTIC SESTERTERPENOID FROM THE MARINE SPONGE LUFFARIELLA VARIABILIS (POLEJAEFF)
Silva, E. Dilip de,Scheuer, Paul J.
, p. 1611 - 1614 (1980)
The structure of manoalide (1), a new sesterterpenoid antibiotic isolated from a marine sponge, has been determined by spectral analysis and chemical transformations.
Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta
Kobayashi,Okamoto,Hayashi,Yokoyama,Sasaki,Kitagawa
, p. 265 - 270 (2007/10/02)
Cytotoxic sesterterpenes, manoalide 25-acetals (1a, 1b), seco-manoalide (2), (E)-neomanoalide (3), (Z)-neomanoalide (4), and heteronemin (6), were isolated from the marine sponge Hyrtios erecta (collected at Amami Island, Kagoshima Prefecture, Japan) by bioassay-guided separation and the absolute configurations of these manoalide family members have been determined. Manoalide 25-acetals (1a, 1b) were shown to exhibit in vivo antitumor activity and to inhibit the DNA-relaxing activity of mouse DNA topoisomerase I and the DNA-unknotting activity of calf thymus DNA topoisomerase II.
