75121-04-9Relevant academic research and scientific papers
Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
supporting information; experimental part, p. 8078 - 8081 (2010/01/16)
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones
Bernini, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Filisti, Eleonora,Sferrazza, Alessio
body text, p. 1480 - 1484 (2009/10/17)
3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and α,β-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chlor
Condensed Heteroaromatic Ring Systems; XVII: Palladium-Catalyzed Cyclization of β-(2-Halophenyl)amino Substituted α,β-Unsaturated Ketones and Esters to 2,3-Disubstituted Indoles
Sakamoto, Takao,Nagano, Tatsuo,Kondo, Yoshinori,Yamanaka, Hiroshi
, p. 215 - 218 (2007/10/02)
Palladium-catalyzed cyclization of β-(2-halophenyl)amino substituted α,β-unsaturated ketones and esters, prepared from 2-haloanilines by three different methods, gave 2,3-disubstituted indoles.
Photocyclization of Aryl Halides. Part 2. The Upper Excited State Reactivity of 3-(2-Halogenoanilino)-1,3-diphenylprop-2-enones; Hydrogen-bonded Configurational Lock in Photosynthesis
Grimshaw, James,de Silva, A. Prasanna
, p. 1010 - 1014 (2007/10/02)
Photocyclization of the internally hidrogen-bonded dibenzoylmethane 2-bromo- and 2-iodo-anils proceed cleanly, though with low quantum yield, to afford a phenanthridine derivative directly and with very little competition from hydrogen abstraction reactio
