75129-08-7

Upstream product

• 2826-25-7 2-(4-methylbenzylidene)malononitrile 
• 17356-08-0 thiourea 
• 104-87-0 4-methyl-benzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1589080-94-3 4-amino-2-(((2-(4-chlorophenyl)thiazol-4-yl)methyl)thio)-6-(p-tolyl)pyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

One pot synthesis of pyrimidine-5-carbonitrile and pyrimidine-5-carboxamide using ammonium chloride under solvent free condition

Abstract: Pyrimidine-5-carbonitrile and pyrimidine-5-carboxamide were synthesized from the various substituted benzaldehyde, malononitrile and cyanoacetamide, urea/thiourea in the presence of ammonium chloride followed by characterization using IR, 1

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.

Reactions with Substituted Acrylonitriles: A Novel Synthesis of Polysubstituted Pyrimidines

3-Arylacrylonitrile-2-thiocarboxamides (1a - d) reacted with S-methylisothiourea to give 4-amino-6-aryl-2-methylmercaptopyrimidine-5-carbonitriles (3a - d).The products 3a - d were also obtained via the reaction of 3-arylacrylonitrile-2-carbonitriles (4a