75142-57-3Relevant academic research and scientific papers
An easy access to fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazones
Yadav, Arvind K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
, p. 2154 - 2156 (2013/03/14)
An efficient and operationally simple synthesis of fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazone surrogates is reported. The reaction can be carried out in a one-pot procedure directly from carbonyl compounds.
Palladium-catalyzed substitution and cross-coupling of benzylic fluorides
Blessley, George,Holden, Patrick,Walker, Matthew,Brown, John M.,Gouverneur, Veronique
supporting information; experimental part, p. 2754 - 2757 (2012/07/16)
Benzylic fluorides are suitable substrates for Pd(0)-catalyzed Tsuji-Trost substitution using carbon, nitrogen, oxygen, and sulfur nucleophiles and for cross-coupling with phenylboronic acid. For the bifunctional substrate 4-chlorobenzyl fluoride, fine-tuning of the reaction conditions allows for the regioselective displacement of either the chlorine or fluorine substituent. The leaving group ability of fluoride vs other groups displaced in substitution is CF3CO2 ≈ p-NO2C6H 4CO2 ≈ OCO2CH3 > F > CH3CO2, a ranking similar to allylic fluorides under Pd catalysis.
Conformational preferences of the fluoromethyl group in p-methylbenzyl fluoride and some derivatives
Schaefer, Ted,Niemczura, Walter P.,Sebastian, Rudy,Kruczynksi, Leonard J.,Danchura, Werner
, p. 1178 - 1182 (2007/10/02)
The coupling over seven bonds between 19F nuclei and protons in p-methylbenzyl fluoride and a series of ring-substituted derivatives is used to estimate the value for a conformation in which the C-F bond lies in a plane perpendicular to the benzene ring.T
