751477-16-4

Upstream product

• 55569-66-9 cytidine 5'-monophosphate-N-acetylneuraminic acid 
• 159889-85-7 2-[(2S,3R,4R,5S,6R)-4-Hydroxy-6-hydroxymethyl-2-phenylsulfanyl-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-isoindole-1,3-dione 
• 133-89-1 UDP-glucose 
• 136882-36-5 2-((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Simplifying oligosaccharide synthesis: Efficient synthesis of lactosamine and siaylated lactosamine oligosaccharide donors

A practical sequence is described for converting D-glucosamine into peracetylated Gal(β-1,4)-GlcNTroc(β1-S)Ph and Neu5Ac(α-2,3)Gal(β-1,4)GlcNTroc(β1-S)Ph building blocks using a synthetic strategy based on chemoenzymatic oligosaccharide synthesis. The known trichloroethoxycarbonyl, N-Troc, protecting group was selected as a suitable protecting group for both enzymatic and chemical reaction conditions. These oligosaccharide building blocks proved effective donors for the β-selective glycosylation of the unreactive OH-3 of a polymeric PEG-bound acceptor and for the axial OH-2 of a mannose acceptor in good yields. The resulting complex oligosaccharides are useful for vaccine and pharmaceutical applications.