75150-40-2

Usage

Uses

Used in Pharmaceutical Industry:
2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE is used as a potential active pharmaceutical ingredient for its demonstrated antibacterial and antifungal properties, making it a candidate for the development of new drugs to combat resistant infections.
Used in Infectious Disease Treatment:
In the field of infectious disease treatment, 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE is considered for its potential role in treating tuberculosis and other infectious diseases, given its studied effects against such pathogens.
Used in Medicinal Chemistry Research:
2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE serves as a subject of interest in medicinal chemistry research, where its structure and properties are further investigated to understand its mechanisms of action and to explore its potential for the development of novel therapeutic agents.

InChI:InChI=1/C8H9ClN2OS/c9-6-1-3-7(4-2-6)13-5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 106-54-7 p-Chlorothiophenol 
• 52377-68-1 ethyl 2-(p-chlorophenylthio)acetate 

Downstream Products

• 81863-62-9 N-1-(4'-chlorophenylthioacetyl)-N-4-(4-methylphenyl)thiosemicarbazide 
• 81863-61-8 C₁₅H₁₄ClN₃OS₂ 
• 81863-64-1 C₁₇H₁₈ClN₃O₂S₂ 
• 81877-70-5 C₁₆H₁₆ClN₃O₂S₂ 
• 81877-71-6 C₁₇H₁₈ClN₃O₂S₂ 

Relevant academic research and scientific papers

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Design, synthesis and bioactivity evaluation of novel thioether derivatives containing a sulfonohydrazide moiety

A series of novel thioether derivatives containing a sulfonohydrazide moiety were synthesized and determined using 1H NMR, 13C NMR, HRMS, and elemental analysis. Their in vitro antibacterial activities against Xanthomonas oryzae pv.

Disulfide derivative containing 1,3,4-oxa(thia)diazole and preparation method and application of derivative

The invention discloses a disulfide derivative containing 1,3,4-oxa(thia)diazole and a preparation method and application of the derivative. The disulfide derivative has the following general formula (as shown in the specification), wherein R1 is selected from 4-chlorphenyl, 4-fluoro-phenyl, benzyl, 4-chloro-benzyl and other substituent groups; R2 is selected from methyl, ethyl, benzyl, 4-chloro-benzyl, ethyl acetate and other substituent groups; X is O or S. The disulfide derivative disclosed by the invention can serve as a medicine or agent for killing nematodes and inhibiting crop bacterium diseases.

2, 5-substituent-1, 3, 4-oxadiazole thioether derivative, preparation method and application thereof

The invention discloses a chalcone derivative containing 1, 1-dichloropropene, a preparation method and application thereof. The derivative has a general formula (I) shown as the specification, wherein R1 is selected from 4-chlorphenyl, 4-fluorophenyl, benzyl, 4-chlorobenzyl and other substituents; R2 is selected from methyl, ethyl, benzyl, 4-chlorobenzyl, ethyl acetate and other substituents. The derivative provided by the invention has the characteristics of simple structure, simple preparation process and low production cost, and has good activity to rice bacterial leaf blight, rice baeterial leaf streak pathogens and caenorhabditis elegans.