75153-66-1Relevant academic research and scientific papers
Synthesis and inhibitory effects on platelet aggregation of phthalazinone derivatives
Sugimoto,Ito,Eguchi,et al.
, p. 223 - 228 (2007/10/02)
7-Ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-2-phenyl-1(2H)-phthalazinon e 7a and its derivatives having various substituents on the benzene ring at the 2 position were prepared and their inhibitory activities on platelet aggregation were assayed. The parent compound and those having an ortho substituent such as fluorine, chlorine atom or a methyl group showed the most potent inhibitory activity. Their inhibitory mechanism on platelet aggregation was assumed to be inhibition of cyclooxygenase, resulting in prevention of prostaglandin synthesis.
