75160-58-6

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 75160-75-7 Imidazo[1,5-a]pyridin-3-yl-(4-methoxy-phenyl)-amine 

Relevant academic research and scientific papers

Synthesis, characterization, cytotoxicity, cell cycle analysis of 3-(4-methoxyphenyl)-1-(pyridin-2-ylmethyl)thiourea and quantum?chemical analyses

Thiourea derivative,3-(4-methoxyphenyl)-1-(pyridin-2-ylmethyl)thiourea, was synthesized. The structure of the synthesized compound (3) was elucidated by IR, UV–visible, 1H NMR, mass Spectrometry, and X-ray single crystal structure. The computat

Reaction of 2-pyridylmethylthiourea derivatives with [(en) 2Co(OSO2CF3)2]+ induces hypodentate coordination of an ethylenediamine ligand

Pyridylmethylthiourea derivatives coordinate with [(en)2Co(OSO 2CF3)2]+ in a tridentate manner resulting in the formation of a hypodentate ethylenediamine ligand. Four ligands were studied: N-(R)phenyl-N′-2-pyridylmethylthiourea (R≤H (1a), CH 3 (1b), OCH3 (1c)) and N-benzyl-N′-2- pyridylmethylthiourea (2). These bind through the sulfur, a deprotonated exo nitrogen, and the pyridyl nitrogen atoms forming four and five-membered rings, respectively. The ligand also coordinates in a bidentate manner through the sulfur and deprotonated endo or exo nitrogen atoms, forming two additional coordination isomers. The solid state structure (X-ray) of one of the bidentate isomers of Co-1b2+ (endo isomer) shows that the coordinated thiourea sulfur induces a structural trans effect of 0.035A on the trans Co-N bond while that of the tridentate isomer of Co-1a3+ confirms the coordination mode of the ligand and the presence of a protonated hypodentate ethylenediamine ligand as suggested by 1H and 13C NMR spectroscopy. CSIRO 2014.

Study of the sulfur atom as hydrogen bond acceptor in N(2)-pyridylmethyl- N′-arylthioureas

The hydrogen acceptor capability of the sulfur atom in the biologically relevant N-2-pyridylmethyl-N′-arilthioureas was explored. N-2-Pyridylmethyl thioreas were selected to avoid the formation of intramolecular six-membered hydrogen-bonded ring. The comp

Polycyclic Azines. III (1). Synthesis of 3-Aminoimidazopyridine Derivatives by Cyclodesulfurization of N'-Substituted-N-(2-pyridylmethyl)thioureas with Dicyclohexylcarbodiimide (2,3)

A series of 3-substituted aminoimidazopyridine derivatives have been synthesized by cyclodesulfurization of a variety of N'-substituted-N-(2-pyridylmethyl)thioureas with dicyclohexylcarbodiimide (DCCD). 1H Nmr spectral analysis of all synthesized c