75163-70-1Relevant academic research and scientific papers
Cross-Coupling Reaction of Chloropyrazines with Acetylenes
Akita, Yasuo,Inoue, Akira,Ohta, Akihiro
, p. 1447 - 1458 (2007/10/02)
Various chloropyrazines were subjected to cross-coupling reaction with acetylenes, such as phenylacetylene, 1-hexyne and propargyl alcohol, in the presence of palladium catalysts, to give the corresponding coupling products in good yields.It was found, th
Alkynyl- and Dialkynyl-quinoxalines. Synthesis of Condensed Quinoxalines
Ames, Donald E.,Brohi, M. Ismail
, p. 1384 - 1389 (2007/10/02)
Condensation of 2-chloro- and 2,3-dichloroquinoxalines with alk-1-ynes in the presence of bis(triphenylphosphine)palladium(II) dichloride and copper(I) iodide gives mono- and di-alkynylquinoxalines.Addition of amines to these products gives stable enamines; hydration gives 2'-oxoalkyl compounds which exist predominantly in the intramolecularly hydrogen-bonded enol form.Condensation of the alkynylquinoxalines with diethyl sodiomalonate, and related compounds, yields pyridoquinoxalin-4-one derivatives. 2-Alkynyl-3-chloroquinoxalines are intermediates for convenient syntheses of pyrroloquinoxalines.
