75166-64-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminononan-2-ol is used as an intermediate in the synthesis of rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt (H825550), a potent inhibitor of phosphodiesterase II (PDE II) with an IC50 of 800nM. 3-aminononan-2-ol does not inhibit other PDE isozymes (IC50 > 100uM), making it a selective inhibitor. It also inhibits the retrograde transport motor, dynein, and adenosine deaminase (Ki = 4nM), making it a potent PDE-2 inhibitor.
In the pharmaceutical industry, 3-aminononan-2-ol plays a significant role in the development of new drugs targeting specific enzymes and pathways, contributing to the advancement of therapeutic options for various diseases and conditions.

InChI:InChI=1/C9H21NO/c1-3-4-5-6-7-9(10)8(2)11/h8-9,11H,3-7,10H2,1-2H3

Upstream product

• 111-25-1 1-bromo-hexane 
• 51714-08-0 3-aminononan-2-one hydrochloride 
• 103539-11-3 (S)-3-((R)-2-Hydroxy-1-phenyl-ethylamino)-nonan-2-ol 
• 103539-08-8 (S)-2-((R)-4-Phenyl-oxazolidin-3-yl)-octanenitrile 
• 103539-09-9 (3S,5R)-3-Hexyl-2-methyl-5-phenyl-morpholin-2-ol 

Downstream Products

• 111209-68-8 erythro-1-<(2-hydroxy-3-nonyl)amino>-2,3-dinitrobenzene 
• 103298-51-7 erythro-9-(2-hydroxy-3-nonyl)-7-deazadenine 
• 119691-06-4 N-[(R)-1-((S)-1-Hydroxy-ethyl)-heptyl]-4-nitro-benzamide 
• 119691-06-4 N-[(R)-1-((R)-1-Hydroxy-ethyl)-heptyl]-4-nitro-benzamide 
• 119691-09-7 (4R,5S)-4-Hexyl-5-methyl-2-(4-nitro-phenyl)-4,5-dihydro-oxazole; hydrochloride 
• 119691-09-7 (4R,5R)-4-Hexyl-5-methyl-2-(4-nitro-phenyl)-4,5-dihydro-oxazole; hydrochloride 
• 119691-08-6 cis-2-hexyl-3-methyl-1-(4-nitrobenzoyl)aziridine 
• 119691-08-6 trans-2-hexyl-3-methyl-1-(4-nitrobenzoyl)aziridine 

Relevant academic research and scientific papers

Stem Cell Culture Methods

The invention provides methods for reversibly inhibiting stem cell differentiation wherein a compound of formula (I) is contacted with a stem cell. The invention further provides a method for preparing a culture medium, a culture medium supplement and a composition comprising a compound of formula (I).

THE STEREOSPECIFIC CYCLIZATION OF A THREO α-BENZAMIDE ALCOHOL TO A CIS N-ACYL AZIRIDINE

Treatment of threo α-benzamide alcohol 3b with triphenylphosphine and diethyl azodicarboxylate gave solely the cis N-acyl aziridine 5b.

ASYMMETRIC SYNTHESIS VII1: ENANTIOSPECIFIC PREPARATION OF β-AMINOALCOHOLS FROM THE N-CYANOMETHYL-4-PHENYL-1,3-OXAZOLIDINE SYNTHON

(-)-N-cyanomethyl-4-phenyl-1,3-oxazolidine 1 has been investigated as chiral template for the enantiospecific synthesis of β-aminoalcohols. (-)-2(R)-hydroxy-3(S)-nonylamine 5a was chosen as a target molecule of the new method.

Adenosine deaminase inhibitors

Pharmaceutical preparations containing compounds of the formula STR1 where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.

Method of imparting immunomodulating and antiviral activity

Compounds of the formula STR1 where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula STR2 where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.

9-(Hydroxy alkyl)purines

There are prepared compounds of the formula STR1 where X is OH, R2 is CH3 and R1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.