75175-25-6Relevant academic research and scientific papers
Phenylpyrazolo[1,5-a]quinazolin-5(4 H)-one: A suitable scaffold for the development of noncamptothecin topoisomerase i (Top1) inhibitors
Taliani, Sabrina,Pugliesi, Isabella,Barresi, Elisabetta,Salerno, Silvia,Marchand, Christophe,Agama, Keli,Simorini, Francesca,La Motta, Concettina,Marini, Anna Maria,Di Leva, Francesco Saverio,Marinelli, Luciana,Cosconati, Sandro,Novellino, Ettore,Pommier, Yves,Di Santo, Roberto,Da Settimo, Federico
, p. 7458 - 7462 (2013)
In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, structurally related to the indenoisoquinoline system precursor of well-known Top1 poisons, was variously decorated (i.e., a substituted
Potential antimalarials. XXII Some 2,4-diamino-5-(3- and 4-trifluoromethylphenyl and 3,4-methylenedioxyphenyl)pyrimidines
Barlin, Gordon B.,Kotecka, Barbara,Rieckmann, Karl H.
, p. 647 - 650 (2007/10/03)
A series of 10 pyrimethamine analogues containing 3′- and 4′-trifluoromethyl and 3′,4′-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine, they were much less active against the drug-resistant K-1 isolate. The 4′-trifluoromethyl compunds, however, showed much smaller differences.
