75178-74-4

Upstream product

• 533923-23-8 C₄₅H₆₀N₆O₁₉ 
• 66567-24-6 3,6'-bis-N-benzyloxycarbonylkanamycin A 
• 74256-73-8 3,6'-bis(N-benzyloxycarbonyl)-3-N-(trifluoroacetyl)kanamycin A 
• 59-01-8 kanamycin A 
• 533923-18-1 C₅₄H₆₃F₃N₆O₂₁ 

Relevant academic research and scientific papers

Probing the functional requirements of the L-haba side-chain of amikacin - Synthesis, 16S A-site rRNA binding, and antibacterial activity

The l-amino group in amikacin was acylated with a variety of 2-hydroxy aminocarboxylic acids to probe the effect of acylation on ribosomal binding and antibacterial activity. The N-hydroxy urea analogue of amikacin (8a) in which the 2-S-hydroxyl-bearing carbon was replaced by an N-OH group was equally active against S. aureus and E. coli in vitro. The analogous tobramycin variant 9 was more active than amikacin.