75179-85-0

Basic information

• Product Name: acetonyl-coenzyme A
• Synonyms: acetonyl-coenzyme A
• CAS NO: 75179-85-0
• Molecular Formula: C₂₄H₄₀N₇O₁₇P₃S
• Molecular Weight: 823.597383
• Mol File: 75179-85-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.86g/cm³
• Refractive Index: 1.708
• CAS DataBase Reference: acetonyl-coenzyme A(CAS DataBase Reference)
• NIST Chemistry Reference: acetonyl-coenzyme A(75179-85-0)
• EPA Substance Registry System: acetonyl-coenzyme A(75179-85-0)

Safety Data

• Hazardous Substances Data: 75179-85-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H40N7O17P3S/c1-13(32)9-52-7-6-26-15(33)4-5-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-8-14-18(47-49(37,38)39)17(34)23(46-14)31-12-30-16-20(25)28-11-29-21(16)31/h11-12,14,17-19,23,34-35H,4-10H2,1-3H3,(H,26,33)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/t14-,17-,18-,19+,23-/m1/s1

Upstream product

• 78-95-5 chloroacetone 
• 85-61-0 coenzyme A 

Relevant articles and documents

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

New mimics of the transition state of spermine/spermidine-N1- acetyltransferase reaction were prepared starting from aminooxy analogues of spermidine or spermine and SH-CoA. The activity depended on the structure of polyamine fragment of the conjugate and best of the synthesized compounds were active at micromolar concentrations. Copyright Taylor & Francis Group, LLC.

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins

A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synthesis of CoA adducts. These CoA adducts undergo enzymatic reaction with Sfp, a phosphopantetheinyl transferase, to afford labeled CurB carrier proteins.