75190-80-6Relevant academic research and scientific papers
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study
Mott, Bryan T.,He, Ran,Chen, Xiaochun,Fox, Jennifer M.,Civin, Curt I.,Arav-Boger, Ravit,Posner, Gary H.
, p. 3702 - 3707 (2013/07/27)
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.
KINETICS OF ESTERIFICATION OF MONOISOPROPYLPHENOLS WITH PHOSPHORYL TRICHLORIDE
Magura, Miroslav,Vojtko, Jan,Ilavsky, Jan
, p. 1311 - 1317 (2007/10/02)
The kinetics of liquid-phase isothermal esterification of POCl3 with 2-isopropylphenol and 4-isopropylphenol have been studied within the temperature intervals of 110 to 130 and 90 to 110 deg C, respectively.The rate constants and activation energies of the individual steps of this three-step reaction have been calculated from the values measured.The reaction rates of the two isomers markedly differ: at 110 deg C 4-isopropylphenol reacts faster by the factors of about 7 and 20 for k1 and k3 respectively.This finding can be utilized in preparation of mixed triarylphosphates, since the alkylation mixture after reaction of phenol with propene contains an excess of 2-isopropylphenol over 4-isopropylphenol.
