75198-04-8Relevant academic research and scientific papers
Strong hyperconjugative interactions limit solvent and substituent influence on conformational equilibrium: The case of cis-2-halocyclohexylamines
Francisco, Camila B.,Fernandes, Cleverton S.,de Melo, Ulisses Z.,Rittner, Roberto,Gauze, Gisele F.,Basso, Ernani A.
, p. 818 - 829 (2019/04/17)
The presence of strong stereoelectronic interactions involving the substituents in cis-2-substituted cyclohexanes may lead to results different from those expected. In this work, we studied the conformational behavior of cis-2-fluoro- (F), cis-2-chloro- (
SYNTHESE DE β-FLUOROAMINES
Toulgui, Ch.,Chaabouni, M. M.,Baklouti, A.
, p. 385 - 391 (2007/10/02)
β-Fluoroamine compounds were obtained from 2-fluorotosylates by action of an excess of amines in dimethyl sulfoxide.The substitution of the tosyl group by amine takes place in all the studied cases whereas the elimination of toluene-p-sulphonic acid (HOTs) is not observed.This process is a good general method for the synthesis of primary, secondary and tertiary β-fluoroamines in acceptable yields.
Preparation of Fluoro Amines by the Reaction of Aziridines with Hydrogen Fluoride in Pyridine Solution
Wade, Tamsir N.
, p. 5328 - 5333 (2007/10/02)
Hydrogen fluoride combines regiospecifically with aziridines (1) to give 2-fluoro amines (6) in good yields.Fluorine attack is in all cases completely directed to the most substituted ring carbon or to the benzylic carbon.The results, for benzylic aziridi
