75201-64-8Relevant academic research and scientific papers
Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety
Amir, Mohd.,Javed, Sadique A.,Hassan, Mohd. Zaheen
experimental part, p. 1261 - 1270 (2012/07/31)
A new class of 4-arylhydrazono-1-benzothiazolyl-3-methylpyrazolin-5-ones (3a-j) and 4-arylazo-1-benzothiazolyl-3,5-dimethylpyrazoles (4a-j) were designed as pharmacophore hybrids between pyrazolinone/pyrazole and benzothiazole moiety. The target molecules were efficiently synthesized by the cyclization of various oxobutyrates/pentane-2,4-dione derivatives with 6-chloro-2- hydrazinobenzothiazole in the presence of glacial acetic acid. The compounds were evaluated for their in vitro antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electron-withdrawing groups in phenyl ring had a promising effect on the antimicrobial activity. Also, correlation study has been used to establish the relationships between the antibacterial activity and physicochemical parameter clogP. Springer Science+Business Media, LLC 2011.
Pyridazine derivatives and related compounds. 23*. synthesis of 3-substituted pyrazolo[3,4-c] pyridazines and their application as disperse dyes
Deeb,Yassin,Ouf,Shehta
experimental part, p. 212 - 222 (2011/08/21)
Acetylacetone and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones and arylazomalononitriles. When refluxed with 3-hydrazino-4,5-diphenyl-1H-pyrazolo-[3,4-c]pyridazine in the presence of ethanol/HCl, they yielded the corresponding 3-[4-(arylazo)-3,5-dimethylpyrazol- 1-yl]- and 3-[3,5-diamino-4-(arylazo)pyrazol-1-yl]-4,5-diphenyl-1H-pyrazolo[3,4- c]pyridazine dyes. The dyes were applied to polyester and polyamide fabrics, and their spectral and fastness properties were measured.
A novel approach to the synthesis of 1,2,3-triazoles and their SAR studies
Sharma, Pratibha,Kumar, Ashok,Upadhyay, Siya,Singh, Jitendra,Sahu, Vinita
experimental part, p. 589 - 602 (2011/11/04)
A series of biologically active 4-acetyl-2-aryl-5-methyl-1-vinyl-2,3- dihydro- 1H-1,2,3-triazole derivatives has been synthesized. The compounds were synthesized in excellent yields (80-85%) and the structures were established on the basis of corresponding IR, 1H NMR, and elemental analysis data. The purity has been ascertained on the basis of chromatographic resolution using acetic acid-toluene (4:6 v/v) as binary eluent. All the compounds (4a-l) have been tested for their antifungal activity against a representative panel of fungal microbes. These synthesized compounds exhibited significant activities against A. niger, C. albicans, C. azyma, and A. flavus. For all the tests conducted, voriconazole was used as the control drug. The hydrophobic parameter (log P) also has been quantized for correlation of structure with biological activity, and a critical evaluation of structure-activity relationship (SAR) has been performed. Birkhaeuser Boston 2009.
A Mechanistic Study on 3-Arylazopentane-2,4-diones and some of its Derivatives at a Hanging Mercury Drop Electrode
Ghoneim,Moharram,Mabrouk,El-Sombati
, p. 229 - 235 (2007/10/03)
The polarographic reduction of 3-arylazopentane-2,4-diones has been investigated in 40% ethanolic B.R. buffer series (pH 2.6-11.7) at mercury cathode. In all pH values four electrons are involved in the reduction cleavge of N=N center followed by reduction of one of the carbonyl groups present in the examined compounds by two electrons confirmed by controlled potential electrolysis. However, the voltammograms of these compounds display a single irreversible cathodic peak over the entire pH range. The different kinetic parameters of the electron transfer process are evaluated where possible using convolution, deconvolution analysis of the recorded cyclic voltammetric data often combined with digital simulation studies.
