75207-72-6

Basic information

• Product Name: 3-Fluorobenzamidine hydrochloride
• Synonyms: 3-FLUORO-BENZAMIDINE HYDROCHLORIDE;3-fluorobenzimidamide hydrochloride;3-Fluoro-benzaMidine HCl;3-FluorobenzenecarboxiMidaMide hydrochloride (1:1);3-FluorobenzaMidine hydrochloride/69491-64-1;3-Fluorobenzene-1-carboximidamide hydrochloride
• CAS NO: 75207-72-6
• Molecular Formula: C₇H₇FN₂*ClH
• Molecular Weight: 174.6
• Mol File: 75207-72-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253 °C at 760 mmHg
• Flash Point: 106.8 °C
• Appearance: /
• Vapor Pressure: 0.0148mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-Fluorobenzamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorobenzamidine hydrochloride(75207-72-6)
• EPA Substance Registry System: 3-Fluorobenzamidine hydrochloride(75207-72-6)

Safety Data

• Hazardous Substances Data: 75207-72-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

3-Fluorobenzamidine, HCl

InChI:InChI=1/C7H7FN2.ClH/c8-6-3-1-2-5(4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 403-54-3 m-Fluorobenzonitrile 
• 133118-49-7 3-fluorobenzenecarboximidic acid methyl ester hydrochloride 

Downstream Products

• 477879-43-9 N-{1-[3-(3-Fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide 
• 76128-68-2 4-phenyl-2-(m-fluorophenyl)pyrimidine 
• 76128-66-0 4-methyl-2-(m-fluorophenyl)pyrimidine 
• 1068970-98-8 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid [5-fluoro-3-(2-pyridin-3-yl-ethyl)-indol-1-yl]-amide 
• 1068970-93-3 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid [5-fluoro-3-(3-hydroxy-3-methyl-butyl)-indol-1-yl]-amide 
• 1068970-92-2 2-(5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indol-3-yl)-2-methyl-propionic acid 
• 1068971-18-5 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethoxy-indol-1-yl)-amide 
• 1068977-28-5 2-(5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indol-3-yl)-2-methyl-propionic acid methyl ester 
• 1068968-57-9 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid [5-fluoro-3-(2-hydroxy-2-methyl-propyl)-indol-1-yl]-amide 
• 1068971-33-4 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethyl-pyrrolo[3,2-b]pyridin-1-yl)-amide 
• 1068968-63-7 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid [5-fluoro-3-(1H-tetrazol-5-yl)-indol-1-yl]-amide 
• 1068971-10-7 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethyl-indol-1-yl)-amide 
• 1068968-14-8 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid [3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-amide 

Relevant articles and documents

BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUENT EFFECTS ON THE pKa VALUES OF META- AND PARA-SUBSTITUTED BENSAMIDINIUM IONS

The pKa values of nine para-substituted derivatives of benzamidine (-NH2, -OH, -OCH3, -CH3, -F, -Cl, -Br, -COOC2H5 and -NO2), as well as four meta-substituted derivatives (-NH2, -CH3, -F, and -NO2), were measured by U.V. difference spectroscopy.The pKa values were interpreted in terms of the resonance structures and a strong correlation between the pKa values and the Hammett ? values of the substituent groups was obtained, with ρ = 1.41 +/- 0.08.The field effects of the substituent groups on the pKa values were calculated using the Kirkwood-Westheimer theory: a very small effect was found in the compounds studied.On the other hand, a strong correlation was observed between the pKa values and the charge densities at the central atom of the substituent groups, as calculated by molecular orbital theory.The analysis of these data suggests that the intramolecular charge transfer is an important factor in the consideration of the mechanism by which the substituent groups affect the pKa values.