752207-01-5Relevant academic research and scientific papers
Octahydrobenzofuran derivative and preparation and application thereof
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Paragraph 0018; 0021-0023, (2020/05/14)
The invention relates to an octahydrobenzofuran derivative and preparation and application thereof, and belongs to the technical field of organic synthesis. The octahydrobenzofuran derivative disclosed by the invention is 7-thiocyano-3, 3-diphenyl-octahydrobenzofuran, does not contain a sulfanilamide structure, has a very good inhibition effect on COX2 and human ovarian cancer cells, and does notcause anaphylactic reaction; besides, the derivative is simple in preparation process, raw materials are cheap and easy to obtain, rare metal is not needed, and the derivative has good application prospects in the field of biological medicine.
Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System
Fujita, Shoji,Abe, Masanori,Shibuya, Masatoshi,Yamamoto, Yoshihiko
supporting information, p. 3822 - 3825 (2015/08/18)
A novel catalytic system using I2 and PhSiH3 for the intramolecular hydroalkoxylation of unactivated alkenes is described. NMR study indicated that in situ generated PhSiH2I is a possible active catalytic species. This catalytic system allows an efficient intramolecular hydroalkoxylation of phenyl-, trialkyl-, and 1,1-dialkyl-substituted alkenes as well as a variety of unactivated monoalkyl- and 1,2-dialkyl-substituted alkenes at room temperature. Mechanistic consideration based on significant experimental observations is also discussed.
Non-superimposable mirror image crystals of enantiomers by spontaneous resolution and the chiral discrimination mechanism
Sohail, Muhammad,Wang, Yao-Feng,Wu, Shao-Xiang,Zeng, Wei,Guo, Ji-Yi,Chen, Fu-Xue
supporting information, p. 695 - 698 (2013/07/26)
Non-superimposable mirror image crystals of both enantiomers (S/R) of cyclic γ-alkenyl alcohol (2) have been recognized and remarkably identified by the naked eye. More interestingly, both crystals are an outcome of most astonishingly H-bond and intermole
Platinum-catalyzed intramolecular hydroalkoxylation of γ- and δ-hydroxy olefins to form cyclic ethers
Qian, Hua,Han, Xiaoqing,Widenhoefer, Ross A.
, p. 9536 - 9537 (2007/10/03)
Reaction of 2,2-diphenyl-4-penten-1-ol with a catalytic mixture of [PtCl2(H2C=CH2)]2 (1 mol %) and P(4-C6H4CF3)3 (2 mol %) at 70 °C for 24 h led to the isolation of 2-
