752218-94-3Relevant academic research and scientific papers
Synthesis of chemically and functionally diverse scaffolds from pentaerythritol
Hanessian, Stephen,Prabhanjan, Hubli,Qiu, Dongxu,Nambiar, Sudhir
, p. 1731 - 1737 (2007/10/03)
Pentaerythritol (2,2-bis-hydroxymethyl-propane-1,3-diol) was converted into a series of mono-, di-, and trisubstituted derivatives, comprising allyl ethers and amino-alkyl ethers, by systematic chemical manipulation of the hydroxy groups. The remaining hydroxymethyl group in the case of the trisubstituted analog was functionalized with ether groups bearing terminal ω-carboxyl or ω-alkene groups. These derivatives are versatile templates and scaffolds for single, double, or triple substitution with appropriate ligands forming amides and esters, and allowing the attachment of the ω-alkene or ω-carboxyl group to solid support for combinatorial chemistry.
