752235-33-9Relevant academic research and scientific papers
O-Protected 3-hydroxy-oxazolidin-2,4-diones: Novel precursors in the synthesis of α-hydroxyhydroxamic acids
Kurz, Thomas,Widyan, Khalid
, p. 2023 - 2027 (2007/10/03)
O-Protected 3-hydroxyoxazolidin-2,4-diones have been prepared in a novel one-pot reaction by subsequent treatment of cyanohydrins with 1,1′-carbonyldiimidazole and O-protected hydroxylamines followed by acidic hydrolysis of the intermediate 4-imino-oxazolidin-2-ones. Decarbonylation of O-protected 3-hydroxyoxazolidin-2,4-diones by catalytic amounts of sodium methoxide, lithium hydroxide, sodium carbonate and caesium carbonate in methanol afforded O-protected α-hydroxyhydroxamic acids in excellent yields. Their deprotection provided a series of novel α-hydroxyhydroxamic acids.
