75227-17-7Relevant academic research and scientific papers
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity
Basilico, Nicoletta,Butini, Stefania,Campiani, Giuseppe,D’alessandro, Sarah,Gemma, Sandra,Ibba, Roberta,Parapini, Silvia,Pozzetti, Luca,Rossi, Sara,Taglialatela-Scafati, Orazio,Taramelli, Donatella
, (2022/01/20)
The potential of natural and synthetic chalcones as therapeutic leads against different pathological conditions has been investigated for several years, and this class of compounds emerged as a privileged chemotype due to its interesting anti-inflammatory
Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents
Guo, Yalan,Wang, Yujie,Li, Haihong,Wang, Ke,Wan, Qi,Li, Jia,Zhou, Yubo,Chen, Ying
, p. 502 - 506 (2018/05/14)
In this work, five new hybrids of phenylsulfonylfuroxan merging 3-benzyl coumarin and their seco-B-ring derivatives 2-6 were designed and synthesized. Among them, compound 3 showed the most potent antiproliferation activities with IC50 values range from 0.5 to 143 nM against nine drug-sensitive and four drug-resistant cancer cell lines. Preliminary pharmacologic studies showed that these compounds displayed lower toxicities than that of lead compound 1. Compound 3 obviously induced the early apoptosis and hardly affected the cell cycle of A2780, which was significantly different from compound 1. Especially, it gave 559- and 294-fold selectivity antiproliferation activity in P-gp overexpressed drug-resistant cancer cell lines MCF-7/ADR and KB-V compared to their drug-sensitive ones MCF-7 and KB, implying that compounds 2-6 might have an extra mechanism of anti-MDR-cancer with P-gp overexpression.
Wacker Oxidation of Terminal Alkenes Over ZrO2-Supported Pd Nanoparticles Under Acid- and Cocatalyst-Free Conditions
Zhang, Zhenzhong,Kumamoto, Yuhya,Hashiguchi, Taishin,Mamba, Tetsuya,Murayama, Haruno,Yamamoto, Eiji,Ishida, Tamao,Honma, Tetsuo,Tokunaga, Makoto
, p. 3482 - 3489 (2017/09/15)
Highly efficient Wacker oxidation of aromatic or aliphatic terminal alkenes into methyl ketones and benzofurans is developed by using reusable Pd0 nanoparticles (NPs) supported on ZrO2 under acid- and cocatalyst-free conditions. Molecular oxygen or air can be utilized as the terminal oxidant, which results in the formation of H2O as the only theoretical byproduct. The activation of the Pd NPs by O2 plays an important role in promoting this reaction. Interestingly, PdO supported on ZrO2 showed no activity. Additionally, the Pd particle size significantly affects the catalytic activity, with an apparent optimal diameter of 4–12 nm. In addition to the heterogeneous catalyst forms, the Pd NPs can be generated from a Pd0 complex during the reaction, and these particles are even recyclable.
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold
Shiao, Hui-Yi,Kuo, Ching-Chuan,Horng, Jim-Tong,Shih, Shin-Ru,Chang, Sui-Yuan,Liao, Chun-Chen,Hsu, John T.-A.,Amancha, Prashanth Kumar,Chao, Yu-Sheng,Hsieh, Hsing-Pang
, p. 1548 - 1554 (2013/03/28)
An efficient, mild and scalable synthesis of angelicin scaffold based compounds was developed. Particularly, the new synthetic route described here circumvents the need for the previously reported key Fries rearrangement step, which uses impractically har
