75227-41-7

Upstream product

• 637038-53-0 methyl N-tosyl-3-(4-methoxyanilino)propionate 
• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 104-94-9 4-methoxy-aniline 
• 75227-25-7 3-[(4-Methoxy-phenyl)-(toluene-4-sulfonyl)-amino]-propionic acid ethyl ester 
• 63767-58-8 ethyl 3?((4?methoxyphenyl)amino)propanoate 
• 42313-52-0 methyl 3-(4-methoxyphenylamino)propanoate 
• 6945-33-1 3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoic acid 
• 637038-54-1 3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoyl chloride 

Downstream Products

• 78439-93-7 trans-N-tosyl-6-methoxy-3-(4-pyridinomethylene)-2,3-dihydro-4-quinolone 
• 76263-73-5 1-[(3S,3aR)-8-Methoxy-3-phenyl-5-(toluene-4-sulfonyl)-3,3a,4,5-tetrahydro-pyrazolo[4,3-c]quinolin-2-yl]-ethanone 
• 23432-39-5 4-hydroxy-6-methoxyquinoline 
• 78431-46-6 3,3a-trans-2(H)-acetyl-3-(4-pyridyl)-5-tosyl-8-methoxy-3,3a,4,5-tetrahydropyrazolo<4,3-c>quinoline 
• 78431-46-6 3,3a-cis-2(H)-acetyl-3-(4-pyridyl)-5-tosyl-8-methoxy-3,3a,4,5-tetrahydropyrazolo<4,3-c>quinoline 
• 103687-97-4 1,4-bis(1,2,3,4-tetrahydro-6-methoxy-4-oxo-1-tosyl-3-quinolinylidenemethyl)piperazine 
• 103688-03-5 8-methoxy-2-phenyl-5-tosyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline 
• 103688-02-4 4,5-dihydro-8-methoxy-5-tosyl-pyrazolo<4,3-c>quinoline 
• 4295-45-8 2-Methoxy-11H-benzo-γ-carbolin 
• 200010-45-3 7-Methoxy-1-(toluene-4-sulfonyl)-1,2,3,5-tetrahydro-benzo[b]azepin-4-one oxime 
• 200010-46-4 7-Methoxy-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-ylamine 
• 200010-40-8 7-Methoxy-1-(toluene-4-sulfonyl)-1,2,3,5-tetrahydro-benzo[b]azepin-4-one 
• 200010-39-5 6-Methoxy-4-methylene-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-quinoline 
• 75227-43-9 2,3-dihydro-3-hydroxymethylene-6-methoxy-1-tosyl-4(1H)-quinolone 

Relevant academic research and scientific papers

2 - [6-methoxy-3 - (2,3-dichlorophenyl) methyl-4-oxo -1,4-dihydro -1 (4H)-quinolyl] method for the preparation of acetic acid

The invention provides a preparation method of 2-(6-methoxy-3-(2, 3-dichlorophenyl) methyl-4-oxo-1, 4-dihydro-1(4H)-quinolyl) acetic acid. The preparation method comprises the following steps: by taking 3-(4-methoxyanilino) sodium propionate as a raw material, performing amino protection treatment to prepare 3-(N-protecting group-4-methoxyanilino) propionic acid, performing Friedel-Crafts acylation reaction to prepare N-protecting group-6-methoxy-2, 3-dihydroquinolinone, and further performing deprotection treatment to prepare an intermediate, namely 6-methoxy-2, 3-dihydro-4 (1H)-quinolinone; by taking the intermediate, namely 6-methoxy-2, 3-dihydro-4 (1H)-quinolinone as a raw material, performing N-alkylation, hydrolysis and condensation reaction to prepare a target product. By adopting the preparation method, the use of a large amount of polyphosphoric acid (PPA) can be avoided, the process is environment-friendly, and the preparation method is more conductive to industrial production.

Structure-activity relationships of antimalarial indoloquinolines

Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents

Studies in Antifertility Agents: Part XXVII - Synthesis of 2-Acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines

N-Tosyl-2,3-dihydro-4-quinolones (12-14), prepared from aniline, m- and p-anisidines by reported procedures, on condensation with araldehydes in the presence of NaOMe give the corresponding 3-arylidene-4-quinolones (15-18).Refluxing of 15-18 with NH2-NH2*H2O in gl.AcOH affords the title compounds, 2-acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines (19-22).The stereochemistry of the title compounds based on the assignments of C3-H, C3a-H, C4-H2 protons has been studied by PMR decoupling experiments.In preliminary screening, compounds 19 and 22 have been found to prevent pregnancy at 20 mg/kg dose in female albino rats, but are ineffective at lower doses.None of the compounds tested shows any significant pharmacological activity.