75235-67-5Relevant academic research and scientific papers
ENCHAINEMENTS HETEROATOMIQUES ET LEURS PRODUITS DE CYCLISATION-V. Esters (6H-Thiazine-1,3 Yl-2) Acetiques et Esters (2H-Dihydro-3,6 Thiazine-1,3 Ylidene-2) Acetiques (ou Maloniques) Diversement Substitues: Synthese et Hydrogenation
Reliquet, Alain,Reliquet, Francoise,Meslin, Jean-Claude,Quiniou, Herve
, p. 143 - 154 (2007/10/02)
Thioacylformamidines readily undergo cycloaddition reactions with acrylic dienophiles giving (1,3-6H-thiazine-2-yl) acetic esters.When the carbon atom α to the CS carries a hydrogen atom, the corresponding condensation products tautomerize to (3,6-2H-dihydro-1,3-thiazine-2-ylidene) acetic (or malonic) esters.A systematic investigation of the hydrogenation of these esters and diesters has provided a means of obtaining selectively (3,6-2H-dihydro-1,3-thiazine-2-yl) acetic esters, potential intermediate in the synthesis of cephems.
