75239-47-3Relevant academic research and scientific papers
Barium nitrate catalyzed one pot synthesis of 1,4-dihydropyridines under solvent free conditions at room temperature
Sharma, Mukul,Agarwal, Nisha,Rawat, Diwan S.
, p. 737 - 739 (2008/09/21)
(Chemical Equation Presented) Barium nitrate acts as an efficient catalyst for the three-component one pot synthesis of 1,4-dihydropyridines. Barium nitrate is a safe chemical, and reaction without the use of organic solvents makes the process eco-friendly.
1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
Coburn,Wierzba,Suto,Solo,Triggle,Triggle
, p. 2103 - 2107 (2007/10/02)
The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.
