75263-45-5

Upstream product

• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 108827-48-1 N^ε-t-butoxycarbonyl-lysyl-O-t-butylthreonyl-phenylalanine methyl ester 
• 17115-08-1 H-Thr(Bu^t)-Phe-OMe*HCl 
• 79385-58-3 N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-lysyl-O-t-butylthreonyl-phenylalanine methyl ester 
• 62120-76-7 Z-Trp-OBt 
• 17115-07-0 Z-Thr(Bu^t)-Phe-OMe 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 10068-65-2 Z-Thr(Bu^t)-ONSu 
• 2389-60-8 Z-Lys(Boc)-OH 
• 79385-59-4 N-benzyloxycarbonyltryptophyl-N^ε-t-butoxycarbonyl-lysyl-O-t-butylthreonyl-phenylalanine methyl ester 

Downstream Products

• 69994-36-1 tryptophyl-N^ε-t-butoxycarbonyl-lysyl-O-t-butylthreonyl-phenylalanine 

Relevant academic research and scientific papers

Tritiated Peptides. Part 11. Synthesis of 6>-, 11>-, and 6,11>-Somatostatin and the Metabolite 1>-Somatostatin

The syntheses are described of somatostatin labelled with tritium singly in the phenylalanine residues at positions 6 and 11 and doubly at residues 6 and 11 to specific radioactivities of 15.5, 13.8 and 14.1 Cim mol-1, respectively, by reductive deiodination of fully-protected precursors.Cysteine residues were proteced by S-trityl groups and the disulphide bridge was formed by iodine oxidation of the tritiated protected precursors.The purity of the products was assessed by acidic hydrolysis, ion-exchange and high-pressure liquid chromatography, and by enzymic digestion of the products modified by reduction and aminoethylation.The synthesis of the metabolite 1>-somatostatin is described.The syntheses of 6>-, 11>- and 6,11>-somatostatin are described.