Dextroamphetamine phosphate is a water-soluble salt derived from Dextroamphetamine, a potent central nervous system stimulant. It is the dextrorotatory isomer of (+)-(S)-methylphenethylamine, which forms salts with sulfuric acid (Dexedrine) and phosphoric acid. The phosphate salt is preferred for parenteral administration due to its higher solubility. Dextroamphetamine phosphate has the (S) configuration and exhibits fewer cardiovascular effects compared to the levorotatory (R)-isomer. It is up to 10 times more potent as an alerting agent and about twice as potent as a psychotomimetic agent. The primary mode of action involves the release of norepinephrine (NE) from the mobile pool of the nerve terminal, with other mechanisms like inhibition of uptake contributing to the overall effects. The alerting actions are related to the increased availability of NE to interact with postsynaptic receptors (α1), while central β-receptor activation is considered the basis for most of the anorexiant effect.
7528-00-9
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Basic information
- Product Name: Dextroamphetamine phosphate
- Synonyms: Dextroamphetamine phosphate;Dextroamphetamine phosphate [usp xx]
- CAS NO:7528-00-9
- Molecular Formula: C9H16NO4P
- Molecular Weight: 233.201401
- EINECS: N/A
- Product Categories: N/A
- Mol File: 7528-00-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 467.2°C at 760 mmHg
- Flash Point: 236.4°C
- Appearance: /
- Density: N/A
- Vapor Pressure: 1.57E-09mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Dextroamphetamine phosphate(CAS DataBase Reference)
- NIST Chemistry Reference: Dextroamphetamine phosphate(7528-00-9)
- EPA Substance Registry System: Dextroamphetamine phosphate(7528-00-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 7528-00-9(Hazardous Substances Data)
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7528-00-9 Usage
Uses
Used in Pharmaceutical Industry:Dextroamphetamine phosphate is used as a central nervous system stimulant for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Its alerting properties and reduced cardiovascular effects make it a preferred choice for these conditions.
Used in Medical Applications:
Dextroamphetamine phosphate is used as a diagnostic tool in the evaluation of patients with suspected sleep apnea. Its alerting effects can help determine the presence and severity of the condition.
Used in Research:
Dextroamphetamine phosphate is utilized in scientific research to study the effects of central nervous system stimulants on various cognitive and behavioral functions. It helps researchers understand the underlying mechanisms of action and develop new treatments for related disorders.
Clinical Use
Dextroamphetamine phosphate is a strongly basic amine, with valuesfrom 9.77 to 9.94 reported. Absorption from the gastrointestinaltract occurs as the lipid-soluble amine. The drug is not extensively protein bound. Varying amounts ofthe drug are excreted intact under ordinary conditions.Check Digit Verification of cas no
The CAS Registry Mumber 7528-00-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,2 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.Calculate Digit Verification of CAS Registry Number 7528-00:
(6*7)+(5*5)+(4*2)+(3*8)+(2*0)+(1*0)=99
99 % 10 = 9
So 7528-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N.H3O4P/c1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2-6,8H,7,10H2,1H3;(H3,1,2,3,4)/t8-;/m0./s1
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Dextroamphetamine phosphate
